Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1927 Jun 30;46(1):81-99. doi: 10.1084/jem.46.1.81.
A study of a malignant disease in rabbits has been made with reference to the presence or absence of a filterable virus, Virus III, in the tumor. The results are analyzed from the standpoint of certain characteristic features of the tumor process in order to determine any differences in degrees of malignancy. It was found that a more severe disease developed in the series in which the virus-bearing tumor was used than in the series in which the tumor was free of the virus, although the differences were not very marked and were not entirely constant. The influence of Virus III as a factor affecting malignancy has been discussed from the standpoint of its possible effect upon (alpha) the tumor cells and (b) the host reaction. It has been suggested that the greater malignancy of the pathological process usually induced by the virus-bearing tumor is attributable to a change in the response of the host to the tumor, which change is of the nature of a decreased resistance associated with the reaction of the host to the virus infection.
对兔子的恶性疾病进行了研究，参考了肿瘤中是否存在可滤过病毒 III。从肿瘤过程的某些特征的角度分析结果，以确定恶性程度的差异。结果发现，在携带病毒的肿瘤系列中，疾病发展更为严重，而在没有病毒的肿瘤系列中则较轻，尽管差异不很明显且不完全恒定。从病毒 III 对（α）肿瘤细胞和（b）宿主反应的可能影响的角度，讨论了它作为影响恶性程度的因素的影响。有人认为，通常由携带病毒的肿瘤引起的更恶性的病理过程归因于宿主对肿瘤反应的变化，这种变化是与宿主对病毒感染的反应相关的降低抵抗力的变化。
