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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Division of Laboratories and Research, New York State Department of Health, Albany.

J Exp Med. 1927 Sep 30;46(4):609-14. doi: 10.1084/jem.46.4.609.

The minimum amount of diphtheria toxin which killed normal mice of from 24 to 30 gm. in weight upon intravenous injection, was found to be between 75 and 100 times the M.F.D. for the guinea pig. When given intraperitoneally, the fatal dose for mice was as high as 200 M.F.D. 2. There was no significant difference in the lethal action of diphtheria toxin for normal mice and mice in which an elimination of the reticulo-endothelial system had been attempted by means of blocking injections of India ink, or splenectomy, or a combination of both operations. 3. Attempts to infect normal mice and mice treated as described with large doses of a highly virulent diphtheria strain were unsuccessful with both groups of animals.

静脉注射时，杀死体重为 24 至 30 克的正常小白鼠所需白喉毒素的最小量，发现为豚鼠的 M.F.D. 的 75 至 100 倍之间。当腹膜内给予时，小白鼠的致死剂量高达 200 M.F.D.。
对于正常小鼠和通过用印度墨水阻断注射、脾切除术或两者联合手术试图消除网状内皮系统的小鼠，白喉毒素的致死作用没有显著差异。
用高毒性白喉菌株的大剂量尝试感染正常小鼠和如所述处理的小鼠，两组动物均未成功。

Division of Laboratories and Research, New York State Department of Health, Albany.

J Exp Med. 1927 Sep 30;46(4):609-14. doi: 10.1084/jem.46.4.609.

The minimum amount of diphtheria toxin which killed normal mice of from 24 to 30 gm. in weight upon intravenous injection, was found to be between 75 and 100 times the M.F.D. for the guinea pig. When given intraperitoneally, the fatal dose for mice was as high as 200 M.F.D. 2. There was no significant difference in the lethal action of diphtheria toxin for normal mice and mice in which an elimination of the reticulo-endothelial system had been attempted by means of blocking injections of India ink, or splenectomy, or a combination of both operations. 3. Attempts to infect normal mice and mice treated as described with large doses of a highly virulent diphtheria strain were unsuccessful with both groups of animals.

静脉注射时，杀死体重为 24 至 30 克的正常小白鼠所需白喉毒素的最小量，发现为豚鼠的 M.F.D. 的 75 至 100 倍之间。当腹膜内给予时，小白鼠的致死剂量高达 200 M.F.D.。
对于正常小鼠和通过用印度墨水阻断注射、脾切除术或两者联合手术试图消除网状内皮系统的小鼠，白喉毒素的致死作用没有显著差异。
用高毒性白喉菌株的大剂量尝试感染正常小鼠和如所述处理的小鼠，两组动物均未成功。