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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York.

J Exp Med. 1928 Jan 31;47(2):261-72. doi: 10.1084/jem.47.2.261.

Blockade of the reticulo-endothelial system by means of one intravenous injection of India ink as well as splenectomy did not alter the course of either Pneumococcus Type I infection or tetanus intoxication in mice. 2. The protective action of Antipneumococcus Type I serum against the corresponding infection, as determined by the injection of in vitro prepared mixtures of serum and culture, was definitely lower in mice which had received one blocking injection of India ink shortly before the test. 3. Titration of tetanus toxin and antitoxin in blocked and splenectomized mice gave results identical with those obtained in normal mice, if in vitro prepared and incubated toxin-antitoxin mixtures were injected. The degree of protection, however, conferred by a preceding dose of antitoxin against subsequent intoxication, was markedly lower in blocked mice than in normal control animals, this difference becoming more pronounced with the increase of the time interval.

通过静脉注射一次印度墨汁和脾切除术来阻断网状内皮系统，并不会改变小鼠Ⅰ型肺炎球菌感染或破伤风毒素中毒的病程。
通过注射体外制备的血清和培养物混合物来确定抗Ⅰ型肺炎球菌血清对相应感染的保护作用，在接受印度墨汁阻断注射后不久接受测试的小鼠中明显降低。
在阻断和脾切除的小鼠中滴定破伤风毒素和抗毒素的结果与在正常小鼠中获得的结果相同，如果注射体外制备和孵育的毒素-抗毒素混合物。然而，先前剂量的抗毒素对随后中毒的保护程度，在阻断的小鼠中明显低于正常对照动物，这种差异随着时间间隔的增加而更加明显。

Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York.

J Exp Med. 1928 Jan 31;47(2):261-72. doi: 10.1084/jem.47.2.261.

Blockade of the reticulo-endothelial system by means of one intravenous injection of India ink as well as splenectomy did not alter the course of either Pneumococcus Type I infection or tetanus intoxication in mice. 2. The protective action of Antipneumococcus Type I serum against the corresponding infection, as determined by the injection of in vitro prepared mixtures of serum and culture, was definitely lower in mice which had received one blocking injection of India ink shortly before the test. 3. Titration of tetanus toxin and antitoxin in blocked and splenectomized mice gave results identical with those obtained in normal mice, if in vitro prepared and incubated toxin-antitoxin mixtures were injected. The degree of protection, however, conferred by a preceding dose of antitoxin against subsequent intoxication, was markedly lower in blocked mice than in normal control animals, this difference becoming more pronounced with the increase of the time interval.

通过静脉注射一次印度墨汁和脾切除术来阻断网状内皮系统，并不会改变小鼠Ⅰ型肺炎球菌感染或破伤风毒素中毒的病程。
通过注射体外制备的血清和培养物混合物来确定抗Ⅰ型肺炎球菌血清对相应感染的保护作用，在接受印度墨汁阻断注射后不久接受测试的小鼠中明显降低。
在阻断和脾切除的小鼠中滴定破伤风毒素和抗毒素的结果与在正常小鼠中获得的结果相同，如果注射体外制备和孵育的毒素-抗毒素混合物。然而，先前剂量的抗毒素对随后中毒的保护程度，在阻断的小鼠中明显低于正常对照动物，这种差异随着时间间隔的增加而更加明显。