Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1928 Jan 1;47(1):23-36. doi: 10.1084/jem.47.1.23.
The guinea pig is subject to cerebral and corneal inoculation of the herpes virus. The effects of the inoculations vary with the strength or degree of virulence of the virus. Weak strains of the virus are implanted on the cerebrum with difficulty and strong strains with ease. Weak strains are quickly suppressed by the brain and strong strains may be passed indefinitely from brain to brain of the guinea pig. Strains of intermediate potency can be passed for a limited number of times only. Weak strains induce keratoconjunctivitis without brain involvement, while strong strains invade the brain from the eye and produce fatal encephalitis. In the latter case, the brain contains active virus inoculable upon the cornea and into the brain of rabbits and guinea pigs. Strains of intermediate potency produce keratoconjunctivitis accompanied by mild symptoms of encephalitis, from which recovery results. The guinea pig serves even more definitely than the rabbit to distinguish grades of virus according to strength or virulence. There is no difference of kind but only of degree of response to inoculation of herpes virus in the rabbit and the guinea pig. The etiology of epidemic encephalitis has not, therefore, been brought appreciably nearer solution by experiments with herpes virus carried out in guinea pigs.
豚鼠易感染脑和角膜的疱疹病毒。接种的效果因病毒的强度或毒力程度而异。弱毒株难以植入大脑，而强毒株则容易植入。弱毒株很快被大脑抑制，而强毒株可能会无限期地从一只豚鼠的大脑传播到另一只豚鼠的大脑。中等效力的毒株只能传递有限的次数。弱毒株引起角膜结膜炎而不涉及大脑，而强毒株则从眼睛侵入大脑并产生致命的脑炎。在后一种情况下，大脑中含有可接种于角膜和兔子及豚鼠大脑的活跃病毒。中等效力的毒株产生角膜结膜炎，并伴有轻度脑炎症状，但可从中恢复。豚鼠比兔子更能根据病毒的强度或毒力来区分病毒的等级。在接种疱疹病毒的兔子和豚鼠中，没有种类上的差异，只有反应程度的差异。因此，用豚鼠进行疱疹病毒实验并没有使流行性脑炎的病因学得到更接近的解决。
