Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1928 Jan 1;47(1):9-22. doi: 10.1084/jem.47.1.9.
In this paper, three strains of the herpes virus have been dealt with. The H.F. II strain was obtained from the subject H.F. 4 years after the H.F. I strain was secured. H.F. is a victim of recurrent herpes. If the subject is also a chronic carrier of the herpes virus, then it is not one, but two or more strains which are persistently carried. The H.F. II strain is of mitigated pathogenic action for the rabbit, as compared with the H.F. I strain; it is to be classed as dermatotropic rather than neurotropic. And yet, in the subject there was no indication that the attack of herpes provoked was different from the other attacks associated with the H.F. I virus. The other two herpes strains derive their interest from the fact that they came also from persons who suffer from repeated attacks of labial herpes. One strain proved highly neurotropic, resembling in this respect the H.F. I strain; the other was hardly neurotropic at all, but was none the less definitely dermatotropic. It may be possible at a later date to secure other samples of virus from these individuals for comparison. The dermatotropic F. strain penetrates to the central nervous system far more readily and certainly from the skin than from corneal surfaces. The recovered inoculated rabbits showed only relative protection to reinoculation of the herpes virus. A notable difference appeared in the degree of protection acquired, on the one hand by the cornea and on the other by the brain. While the one was partial, the other was complete. The complete resistance of the brain was shown (a) by the complete failure of the intracerebral inoculation, and (b) by the absence of circling movements following corneal inoculation.
本文处理了三种疱疹病毒株。H.F. II 株是在获得 H.F. I 株 4 年后从 H.F. 患者身上分离得到的。H.F. 是复发性疱疹的患者。如果该患者也是疱疹病毒的慢性携带者，那么持续携带的就不是一种，而是两种或更多种病毒株。与 H.F. I 株相比，H.F. II 株对兔的致病作用较弱；它属于皮肤嗜性而不是神经嗜性。然而，在该患者中，没有迹象表明疱疹发作与其他与 H.F. I 病毒相关的发作不同。另外两种疱疹病毒株的有趣之处在于，它们也来自反复发生唇疱疹发作的患者。一种病毒株具有高度神经嗜性，在这方面与 H.F. I 株相似；另一种病毒株几乎没有神经嗜性，但仍然是明确的皮肤嗜性。将来有可能从这些个体中获得其他病毒样本进行比较。皮肤嗜性 F 株从皮肤向中枢神经系统的渗透远比从角膜表面更迅速和肯定。接种的恢复兔子对再次接种疱疹病毒仅显示相对的保护作用。角膜和大脑获得的保护程度有明显差异。一方面角膜的保护是部分的，另一方面大脑的保护是完全的。大脑的完全抵抗力表现在：(a)脑内接种完全失败，(b)角膜接种后无旋转运动。
