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2
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4
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Immunological basis in the aetiology of rheumatic fever (a review).风湿热病因学的免疫学基础（综述）
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本文引用的文献

1
Studies in Immunity to Tuberculosis : Experimental studies on the cutaneous Reaction to Tuberculo-Protein. First Paper-Factors Governing the Reaction.结核病免疫研究：结核蛋白皮肤反应的实验研究。第一篇论文——影响反应的因素
J Med Res. 1916 Sep;35(1):1-23.
2
REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : III. REACTIONS AT THE SITE OF INJECTION.家兔皮内注射肺炎球菌及其产物的反应：Ⅲ. 注射部位的反应。
J Exp Med. 1930 Feb 28;51(3):463-72. doi: 10.1084/jem.51.3.463.
3
REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : II. SKIN REACTIONS IN INTRAVENOUSLY IMMUNIZED ANIMALS.家兔对非溶血性链球菌的反应：Ⅱ. 静脉免疫动物的皮肤反应。
J Exp Med. 1929 Apr 30;49(5):883-97. doi: 10.1084/jem.49.5.883.
4
STUDIES ON INDIFFERENT STREPTOCOCCI : III. THE ALLERGIZING CAPACITY OF DIFFERENT STRAINS.非溶血性链球菌的研究：III. 不同菌株的致敏能力。
J Exp Med. 1929 Mar 31;49(4):637-47. doi: 10.1084/jem.49.4.637.
5
REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. GENERAL TUBERCULIN-LIKE HYPERSENSITIVENESS, ALLERGY, OR HYPERERGY FOLLOWING THE SECONDARY REACTION.家兔对非溶血性链球菌的反应：I. 继二次反应之后的一般结核菌素样超敏反应、过敏或过敏反应。
J Exp Med. 1929 Mar 31;49(4):615-36. doi: 10.1084/jem.49.4.615.
6
ON THE NATURE OF BACTERIAL ALLERGIES.论细菌性过敏的本质。
J Exp Med. 1925 Jan 1;41(1):159-77. doi: 10.1084/jem.41.1.159.

家兔对非溶血性链球菌的反应：III. 致敏方式的研究。

REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : III. A STUDY OF MODES OF SENSITIZATION.

机构信息

Hospital of The Rockefeller Institute for Medical Research.

出版信息

J Exp Med. 1930 Jun 30;52(1):1-22. doi: 10.1084/jem.52.1.1.

DOI:10.1084/jem.52.1.1
PMID:19869742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2131870/
Abstract

The most satisfactory method thus far found for the induction and maintenance of a high degree of hypersensitiveness-"allergy," "hyperergy"-against non-hemolytic streptococci consists in the repeated production of small focal lesions with minimal doses of bacteria. After a preliminary sensitizing period of about 2 weeks' duration with either large initial, or small multiple daily inoculations, the later foci need be produced only at 7 to 10 day intervals. Chronicity of low-grade infection appears to be an important factor in the attainment of a high degree of hypersensitiveness.

摘要

迄今为止，发现最令人满意的方法是通过重复使用小剂量细菌来产生小的局灶性病变，从而诱导和维持对非溶血性链球菌的高度过敏状态——“过敏”、“超敏”。在经过大约 2 周的初始大剂量或每日多次小剂量接种的初步致敏期后，后期只需每 7 至 10 天产生一次焦点。慢性低度感染似乎是获得高度过敏状态的一个重要因素。