Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1930 Sep 30;52(4):539-45. doi: 10.1084/jem.52.4.539.
In a study of the distribution of the specific types of Friedländer's bacillus, it is shown that: (1) Of 80 strains 52 per cent belong to Type A, 15 per cent to Type B, 9 per cent to Type C, and 24 per cent to Group X. (2) Type A contains for the most part strains derived from diseases of man and more than 70 per cent are associated with pneumonia in man. (3) Type B includes the greatest number of strains from animal sources, while the heterogeneous strains comprising Group X come from the greatest variety of diseases. It was demonstrated that in a patient suffering with pneumonia due to Friedländer's bacillus (Type A), a specific precipitin reaction of the urine occurred in the corresponding (Type A) immune serum. A study of the sugar fermentation reactions of Friedländer's bacillus shows that (1) there is no correlation between serological type and fermentative activity; (2) the fermentation reactions are variable and therefore not reliable for distinguishing Friedländer's bacillus from closely allied organisms; (3) the strains of Group X show the greatest variation in fermentation, and (4) of 15 strains unable to ferment lactose, 13 belong to Type A.
(1)80 株菌株中,52%属于 A 型,15%属于 B 型,9%属于 C 型,24%属于 X 组。(2)A 型主要包含源自人类疾病的菌株,超过 70%与人类肺炎有关。(3)B 型包含最多源自动物源的菌株,而构成 X 组的异质菌株则来自最多样化的疾病。在一例因弗氏杆菌(A 型)引起肺炎的患者中,相应的(A 型)免疫血清中出现了特异性沉淀反应。对弗氏杆菌的糖发酵反应的研究表明:(1)血清型与发酵活性之间没有相关性;(2)发酵反应是可变的,因此不能可靠地区分弗氏杆菌与密切相关的生物体;(3)X 组的菌株在发酵方面表现出最大的变异性;(4)在 15 株不能发酵乳糖的菌株中,有 13 株属于 A 型。