Department of Bacteriology and Immunology, New York University and Bellevue Hospital Medical College, New York.
J Exp Med. 1931 Jan 1;53(1):93-107. doi: 10.1084/jem.53.1.93.
The mutual relationship of the anticarbohydrate precipitins and the protective action in antipneumococcus sera to the soluble specific substance was investigated. The assumption is made that there exists in antipneumococcus serum, type-specific protective antibody which is distinct from the anticarbohydrate precipitins and is not neutralized by the soluble specific substance. This assumption is based upon the following observations in experiments which were conducted primarily with Type I antipneumococcus horse serum. 1. Lack of proportionality between the quantity of SSS added and the amount of anticarbohydrate precipitin and protective action neutralized. 2. Protective capacity of specific precipitates (SSS-precipitin complex) is accounted for on the basis of a liberation of non-specifically adsorbed protective antibody. 3. SSS only partially neutralizes the protective action of antipneumococcus serum in vivo. 4. Type-specific protective antibody remains in antipneumococcus serum after complete precipitation of the anticarbohydrate precipitins. 5. This residual type-specific protective antibody is not neutralized by additional SSS nor by absorption with heterologous pneumococci; it is definitely absorbed by the homologous pneumococci.
研究了抗碳水化合物沉淀素与抗肺炎球菌血清中的保护性作用与可溶性特异物质之间的相互关系。假设抗肺炎球菌血清中存在与抗碳水化合物沉淀素不同的、针对特定类型的保护性抗体，并且不受可溶性特异物质的中和。这一假设基于以下观察结果：在主要针对 I 型肺炎球菌马血清进行的实验中：1. 添加 SSS 的量与中和的抗碳水化合物沉淀素和保护作用之间缺乏比例关系。2. 特异性沉淀物（SSS-沉淀素复合物）的保护能力是基于非特异性吸附的保护性抗体的释放来解释的。3. SSS 仅部分中和肺炎球菌血清在体内的保护作用。4. 碳水化合物沉淀素完全沉淀后，抗肺炎球菌血清中仍存在针对特定类型的保护性抗体。5. 这种残留的针对特定类型的保护性抗体不受额外的 SSS 中和，也不被吸收异源肺炎球菌吸收；它肯定被同源肺炎球菌吸收。
