Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
J Exp Med. 1931 Jul 31;54(2):233-48. doi: 10.1084/jem.54.2.233.
The clinical picture and gross pathology of spontaneous and experimental "mad itch" have been described and the inciting agent has been shown to be a filtrable virus. It has been possible to prepare virucidal serum capable of neutralizing the virus. Fatal infections are regularly produced in rabbits when the virus is administered subcutaneously, intracerebrally, intravenously, intratesticularly, intraperitoneally, intranasally, or when it is dropped on a scarified area of skin. Its infectivity for other species by various routes is reported upon. The rabbit, guinea pig, white rat, white mouse, gray field mouse, cow, cat, duck, chicken, and hog are susceptible to experimental infection. The disease is not contagious under laboratory conditions and the virus is restricted in the animal body largely to the region of inoculation and the lung. The virus can be stored for relatively long periods in 50 per cent glycerol or in the dried state. A comparison of "mad itch" with pseudorabies leads to the tentative conclusion that the inciting agents of both are the same, although the strains of the two viruses that are under study possess readily demonstrable differences.
自发性和实验性“狂痒病”的临床和大体病理学已有描述，引发剂已被证明是一种可过滤的病毒。已经有可能制备出能够中和病毒的抗病毒血清。当皮下、脑内、静脉内、睾丸内、腹腔内、鼻内或当它滴在划痕皮肤区域时，病毒会定期在兔子中引起致命感染。报告了其通过各种途径对其他物种的感染力。兔子、豚鼠、白老鼠、小白鼠、灰色田鼠、牛、猫、鸭、鸡和猪易受实验感染。在实验室条件下，这种疾病不具有传染性，病毒在动物体内主要局限于接种部位和肺部。病毒可以在 50%甘油或干燥状态下相对长时间储存。将“狂痒病”与伪狂犬病进行比较，得出一个试探性结论，即两者的引发剂是相同的，尽管正在研究的两种病毒的毒株具有明显的差异。
