Hamet P, Mongeau E, Lambert J, Bellavance F, Daignault-Gélinas M, Ledoux M, Whissell-Cambiotti L
Clinical Research Institute of Montreal, University of Montreal, Canada.
Hypertension. 1991 Jan;17(1 Suppl):I150-4. doi: 10.1161/01.hyp.17.1_suppl.i150.
It has been reported that calcium intake may effectively modulate the expression of hypertension affected by sodium. The present study extends our previous analysis of this calcium-sodium interaction, additionally demonstrating that calcium, sodium, and alcohol intake further contribute to both systolic and diastolic blood pressures in normotensive subjects. Calcium intake was related to lower blood pressure over all ranges of sodium and alcohol intake, and alcohol intake contributed positively and significantly to both systolic and diastolic blood pressures. However, sodium was associated with increased blood pressure only at low calcium intake, particularly in subjects who consumed large amounts of alcohol. This study points to a significant interaction among sodium, calcium, and alcohol intake as determinants of blood pressure, which, together with gender and weight, contribute to 31% of systolic blood pressure and with the addition of age to 36% of the variance in diastolic blood pressure.
据报道，钙的摄入量可能有效地调节受钠影响的高血压表达。本研究扩展了我们之前对这种钙 - 钠相互作用的分析，此外还表明，钙、钠和酒精的摄入量进一步影响正常血压受试者的收缩压和舒张压。在所有钠和酒精摄入范围内，钙的摄入量与较低的血压相关，并且酒精摄入量对收缩压和舒张压均有显著的正向影响。然而，仅在低钙摄入量时，钠才与血压升高有关，特别是在大量饮酒的受试者中。这项研究指出，钠、钙和酒精摄入量之间存在显著的相互作用，它们作为血压的决定因素，与性别和体重一起，导致收缩压变异的31%，再加上年龄则导致舒张压变异的36%。
