特应性皮肤反应和循环抗体在大叶性肺炎中的作用：II. 抗肺炎球菌血清治疗的病例。

SPECIFIC CUTANEOUS REACTIONS AND CIRCULATING ANTIBODIES IN THE COURSE OF LOBAR PNEUMONIA : II. CASES TREATED WITH ANTIPNEUMOCOCCIC SERA.

机构信息

Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston.

出版信息

J Exp Med. 1931 Oct 31;54(5):653-67. doi: 10.1084/jem.54.5.653.

DOI:10.1084/jem.54.5.653

PMID:19869948

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2132058/

Abstract

Characteristic cutaneous responses to the type-specific protein-free carbohydrates of both Type I and Type II pneumococci have been "produced" in cases of lobar pneumonia due to either of these types by the intravenous injection of concentrated bivalent (Types I and II) antipneumococcic sera (Felton). 2. A positive cutaneous response to the specific polysaccharide of Type II pneumococci has been passively transferred from human cases convalescing from this infection to a patient suffering from pneumonia due to this organism. 3. The cutaneous responses to the type-specific polysaccharides and circulating antibodies were studied in 51 cases of lobar pneumonia. Positive cutaneous reactions were, in most instances, associated with recovery, even when purulent complications were present. Failure to elicit a positive reaction was usually followed by a fatal outcome. 4. The positive reactions in patients who were treated with concentrated sera and recovered were most often elicited within 24 hours after the first dose and after a total of 40 cc. had been given. 5. The positive skin reactions obtained after the administration of specific antisera were associated with the presence of mouse protective antibodies and agglutinins in the sera of the patients. 6. The immune reactions in serum treated cases receiving repeated inoculations with the specific carbohydrates disappeared more rapidly than in similar cases receiving no antiserum. It is suggested that the administration of antisera in someway interferes with the production of antibodies by the intracutaneously injected carbohydrates.

摘要

通过静脉注射浓缩二价（I 型和 II 型）抗肺炎球菌血清（Felton），在由这两种类型之一引起的大叶性肺炎病例中，已经“产生”了对 I 型和 II 型肺炎球菌的特异性无蛋白碳水化合物的特征性皮肤反应。
从患有这种感染的人类病例中被动转移到因这种生物体引起肺炎的患者身上，对 II 型肺炎球菌特异性多糖的阳性皮肤反应已被转移。
在 51 例大叶性肺炎病例中研究了对型特异性多糖和循环抗体的皮肤反应。在大多数情况下，阳性皮肤反应与恢复相关，即使存在脓性并发症也是如此。未能引起阳性反应通常会导致致命后果。
在接受浓缩血清治疗并康复的患者中，阳性反应通常在首次给药后 24 小时内且总共给予 40cc 后引起。
在给予特异性抗血清后获得的阳性皮肤反应与患者血清中存在小鼠保护抗体和凝集素有关。
在接受重复接种特异性碳水化合物的血清治疗病例中，免疫反应比接受无抗血清的类似病例消失得更快。有人认为，抗血清的给药以某种方式干扰了经皮注射碳水化合物产生抗体的能力。