Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1931 Oct 31;54(5):747-60. doi: 10.1084/jem.54.5.747.
A male mouse from a strain with a high incidence of spontaneous lung tumors was crossed with several females derived from a low tumor strain. The first generation of offspring were then backcrossed to individuals of the original strains. The resulting two groups of offspring differed significantly in the incidence of spontaneous tumors of the lung. These facts are discussed in relation to others previously discovered. It seems clear from the evidence presented that there are among mice constitutional types which differ in incidence of tumors of the lung and that the differences are inherited. The number of genetic factors involved has not been determined. No influence of sex was apparent. The possibility of there being genetic factors which affect tumor age will be dealt with later.
一只来自自发性肺肿瘤高发品系的雄性老鼠与几只来自低肿瘤品系的雌性老鼠杂交。第一代后代然后与原始品系的个体回交。由此产生的两组后代在自发性肺肿瘤的发生率上有显著差异。这些事实与以前发现的其他事实有关。从提出的证据来看，老鼠之间显然存在着在肺肿瘤发病率方面不同的体质类型，而且这种差异是可以遗传的。所涉及的遗传因素的数量尚未确定。性别没有明显的影响。稍后将讨论是否存在影响肿瘤年龄的遗传因素的可能性。
