Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1925 Oct 31;42(5):693-700. doi: 10.1084/jem.42.5.693.
The external application of tar to a number of separated areas on the surface of mice, in such fashion that no single area is irritated sufficiently long to cause lesions of the skin, has resulted in a very high incidence of lung tumors. This incidence ranged from 60.0 per cent in one experiment to 78.3 per cent in another. Control mice from the same stock but from 3 to 6 months older, and for that reason the more liable to spontaneous lung tumors, failed to show a single instance of such growths. Even in a stock in which spontaneous lung tumors had been frequent, the incidence for corresponding age periods has never been above 5.5 per cent while the average has been between 1 and 2 per cent over a period of years. The tumors in the tar-painted animals occur as small white nodules, either single or multiple. They are typical epithelial neoplasms, identical histologically with those described by previous authors as occurring spontaneously in mice. Some possible factors in the causation of the tumors are briefly discussed.
将焦油涂抹在老鼠表面的多个分离区域上，这样就不会有任何一个区域受到足够长时间的刺激而导致皮肤损伤，从而导致肺部肿瘤的发病率非常高。在一个实验中，发病率从 60.0%到另一个实验中的 78.3%不等。来自同一批老鼠的对照组老鼠年龄大 3 到 6 个月，因此更容易患上自发性肺肿瘤，但没有一例出现这种肿瘤。即使在自发性肺肿瘤经常发生的品系中，相应年龄段的发病率也从未超过 5.5%，而多年来的平均发病率在 1%到 2%之间。在涂焦油的动物中，肿瘤呈白色小结节，单发或多发。它们是典型的上皮性肿瘤，在组织学上与以前的作者描述的在老鼠中自发发生的肿瘤相同。简要讨论了导致肿瘤的一些可能因素。
