Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston.
J Exp Med. 1932 Jan 31;55(2):169-79. doi: 10.1084/jem.55.2.169.
Pleuritic exudates from patients with lobar pneumonia may be sterile or infected. Sterile fluids, at or about the time of crisis, contain actively acquired antibodies similar to those in the blood serum. Infected fluids do not contain such antibodies, presumably because of the presence in them of large amounts of soluble specific substance. Sterile fluids from patients treated with immune sera have both horse serum and antibodies similar to those injected. Infected fluids from serum-treated cases contain horse serum and such heterologous antibodies as were contained in the therapeutic sera together with homologous soluble specific substance. The concentration of horse serum and antibodies in pneumonic fluids is usually the same or somewhat less than that of the corresponding blood sera.
大叶性肺炎患者的胸腔渗出液可以是无菌的，也可以是感染性的。在危急期的无菌渗出液中含有与血清中相似的主动获得的抗体。感染性渗出液中不含有这种抗体，这大概是因为其中存在大量可溶性特异物质。用免疫血清治疗的患者的无菌渗出液既含有马血清又含有与注入的血清相似的抗体。经血清治疗的病例的感染性渗出液含有马血清和治疗血清中所含的同种异体抗体以及同源可溶性特异物质。肺炎患者的胸腔渗出液中的马血清和抗体的浓度通常与相应的血清相同或稍低。
