抗链球菌溶血素。
ANTIGENIC STREPTOCOCCAL HEMOLYSIN.
机构信息
Belmont Laboratories (London County Council), Sutton, Surrey, England.
出版信息
J Exp Med. 1932 Jan 31;55(2):267-80. doi: 10.1084/jem.55.2.267.
Abstract
- Normal serum, used in cultures for preparation of the streptolysin, modifies the properties of the streptolysin, causing delayed hemolysis, increased filterability, resistance to oxidation or reduction, and absence of antigenicity. 1. Streptolysin prepared without serum is an active antigen. 3. Similar temperatures are required to destroy the antigenic activity of serum-free streptolysin and the skin reactivity of Dick toxin. 4. Scarlet fever antitoxin contains antistreptolysin which does not neutralise serum streptolysin and which can be detected only by titration against serum-free streptolysin. 5. The antihemolysin which neutralises serum-free streptolysin is species-specific but not type-specific.
摘要
- 正常血清，用于制备链球菌溶血素的培养，可改变链球菌溶血素的性质，导致迟发性溶血、增加滤过性、对氧化或还原的抵抗力以及无抗原性。1. 无血清制备的链球菌溶血素是一种活性抗原。3. 要破坏无血清链球菌溶血素的抗原活性和 Dick 毒素的皮肤反应性，需要类似的温度。4. 猩红热抗毒素含有抗链球菌溶血素，它不能中和血清链球菌溶血素，只能通过对无血清链球菌溶血素的滴定来检测。5. 能中和无血清链球菌溶血素的抗溶血素是种特异性的，但不是型特异性的。
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