恙虫病立克次体在跳蚤体内的繁殖。
THE MULTIPLICATION OF THE VIRUS OF MEXICAN TYPHUS FEVER IN FLEAS.
机构信息
The American Hospital, Mexico City, Mexico, and the Laboratory of the Department of Bacteriology and Immunology, Harvard University Medical School, Boston, Massachusetts.
出版信息
J Exp Med. 1932 Jan 31;55(2):307-23. doi: 10.1084/jem.55.2.307.
THE VIRUS OF MEXICAN TYPHUS HAS BEEN SHOWN TO MULTIPLY ABUNDANTLY IN THE FOLLOWING SPECIES OF FLEAS
Xenopsylla cheopis, Ceratophyllus fasciatus, Leptopsylla musculi, Ctenocephalus canis, Ctenocephalus felis. In all fleas, Rickettsia prowazeki was demonstrated within the epithelial cells of the stomach and within the cells of the Malpighian tubules. Whereas in infected lice enormous numbers of these organisms are discharged from the disintegrating cells into the intestinal content, only few Rickettsiae are found in the lumen of the fleas' intestines. They are held back by the peritrophic membrane, which covers the mucosa of the entire stomach. Rickettsiae seem to enter the lumen of the gut almost exclusively by the route of the Malpighian tubules. Observations were made which seem to indicate that the fleas recover from the infection and that they are able to regenerate the partly destroyed intestinal mucosa. An explanation is given for the relative harmlessness of fleas as vectors of typhus.
墨西哥斑疹伤寒病毒已被证明在以下几种跳蚤中大量繁殖
印鼠客蚤、角叶蚤、鼠蚤、犬栉首蚤、猫栉首蚤。在所有跳蚤中，普氏立克次体被证明存在于胃的上皮细胞和马尔皮基氏小管的细胞内。而在受感染的虱子中，大量的这些生物体从崩解的细胞中排入肠内容物中，只有少数立克次体在跳蚤肠道的腔中被发现。它们被覆盖整个胃黏膜的围食膜所阻挡。立克次体似乎几乎完全通过马尔皮基氏小管进入肠道腔。观察结果似乎表明，跳蚤从感染中恢复过来，并且能够再生部分受损的肠道黏膜。对跳蚤作为斑疹伤寒媒介的相对无害性给出了解释。
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