睾丸提取物对移植性小鼠肿瘤生长的影响。
THE EFFECT OF TESTICLE EXTRACT ON THE GROWTH OF TRANSPLANTABLE MOUSE TUMORS.
机构信息
Laboratories of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1932 Feb 29;55(3):455-63. doi: 10.1084/jem.55.3.455.
Grafts of a transplantable mouse sarcoma designated as No. 180, and those of an attenuated strain of a more malignant Sarcoma S/37, treated with testicle extract, either fail to grow on inoculation or result in tumors of a lower growth rate than the controls. Autografts of spontaneous mouse tumors so treated show little if any effect, while the Bashford adenocarcinoma and the unattenuated S/37 are unaffected. The factor in testicle extract responsible for the retarding activity passes readily through a Berkefeld filter and is thermostable.
经睾丸提取物处理的可移植鼠肉瘤 180 号和一种恶性更强的 S/37 肉瘤减毒株的移植物，要么在接种时无法生长，要么导致肿瘤的生长速度比对照物低。经同样处理的自发鼠肿瘤的自体移植物几乎没有效果，而 Bashford 腺癌和未减毒的 S/37 则不受影响。睾丸提取物中负责延缓活性的因子很容易通过 Berkefeld 过滤器，并且热稳定。
Zotero 插件