肺炎球菌免疫机制的研究：通过杀菌测量法进行的研究 II. 抗碳水化合物抗体与该生物体的特异性产物之间的反应。
AN EXAMINATION OF THE MECHANISM OF PNEUMOCOCCUS IMMUNITY BY MEANS OF BACTERICIDAL MEASUREMENTS : II. THE REACTION BETWEEN THE ANTICARBOHYDRATE ANTIBODY AND TYPE-SPECIFIC PRODUCTS OF THE ORGANISM.
机构信息
Department of Bacteriology and Immunology, Harvard University Medical School, Boston.
出版信息
J Exp Med. 1932 Mar 31;55(4):519-30. doi: 10.1084/jem.55.4.519.
Abstract
- There is in the filtrate of a 5 day broth culture of Type III pneumococcus a type-specific substance which has a very powerful antibactericidal action. If the precipitinogen content of the broth filtrate and the specific carbohydrate is taken as the basis of comparison, it requires approximately one thousand times as much antiserum to neutralize the broth filtrate as is necessary to neutralize the specific carbohydrate. The active substance in the broth filtrate appears to be related to the specific carbohydrate. Its possible nature is discussed. 2. A similar substance, but in stronger concentration, was found in the filtrate of a lung from a Type III pneumonia autopsy. The influence of this substance on the disease is discussed. 3. One specimen of Type III convalescent blood, though comparatively weak in anticarbohydrate antibody (precipitin) was better able to neutralize the broth filtrate and the lung filtrate than a corresponding mixture of normal blood and antiserum. Two other specimens of Type II convalescent blood neutralized the Type III broth filtrate efficiently.
摘要
在 III 型肺炎球菌 5 天肉汤培养物的滤液中，有一种具有很强杀菌作用的特异性物质。如果以肉汤滤液的沉淀原含量和特定碳水化合物为基础进行比较，那么需要一千倍以上的抗血清才能中和肉汤滤液，而中和特定碳水化合物所需的抗血清则要少得多。肉汤滤液中的活性物质似乎与特定碳水化合物有关。对其可能的性质进行了讨论。
在 III 型肺炎尸检肺的滤液中发现了一种类似的物质，但浓度更高。讨论了这种物质对疾病的影响。
虽然 III 型恢复期血液的抗碳水化合物抗体（沉淀素）相对较弱，但它比相应的正常血液和抗血清混合物更能中和肉汤滤液和肺滤液。另外两份 II 型恢复期血液能有效地中和 III 型肉汤滤液。
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