糖蛋白的化学免疫研究：V. 用 III 型肺炎球菌荚膜多糖与异源蛋白结合制备的抗原的免疫学特异性。
CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : V. THE IMMUNOLOGICAL SPECIFITY OF AN ANTIGEN PREPARED BY COMBINING THE CAPSULAR POLYSACCHARIDE OF TYPE III PNEUMOCOCCUS WITH FOREIGN PROTEIN.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1931 Jul 31;54(3):437-47. doi: 10.1084/jem.54.3.437.
Abstract
- Type-specific antipneumococcus immunity has been induced in rabbits by immunization with antigen prepared by combining a specific derivative of the capsular polysaccharide of Type III Pneumococcus with globulin from horse serum. 2. Rabbits immunized with this antigen acquire active immunity against infection with virulent Type III pneumococci. 3. The sera of the immune rabbits contain type-specific antibodies which precipitate the Type III capsular polysaccharide, agglutinate Type III pneumococci, and specifically protect mice against Type III infection. 4. The experimental data are discussed with reference to: (1) the concurrence in the immune sera of type-specific antibodies for Pneumococcus and precipitins for horse globulin; (2) the determining influence of the capsular polysaccharide on the specificity of the antigen as a whole; (3) the unity of the type-specific precipitins, agglutinins, and protective antibodies induced by a single component of the pneumococcus in chemical union with an unrelated, animal protein.
摘要
通过用 III 型肺炎球菌荚膜多糖的特异衍生物与马血清球蛋白结合制备抗原免疫兔子，诱导了针对各型肺炎球菌的特异性抗肺炎球菌免疫。
用这种抗原免疫的兔子获得了针对 III 型强毒肺炎球菌感染的主动免疫力。
免疫兔的血清含有特异性抗体，能沉淀 III 型荚膜多糖，凝集 III 型肺炎球菌，并能特异性地保护小鼠免于 III 型感染。
实验数据的讨论参考了：（1）免疫血清中肺炎球菌特异性抗体和马球蛋白沉淀素的并存；（2）荚膜多糖对整个抗原特异性的决定作用；（3）由肺炎球菌的单一成分与一种无关动物蛋白化学结合而诱导的特异性沉淀素、凝集素和保护性抗体的统一性。
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