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定量研究沉淀反应：以交叉沉淀实例说明抗原-抗体结合中多个反应基团的作用。

QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : THE ROLE OF MULTIPLE REACTIVE GROUPS IN ANTIGEN-ANTIBODY UNION AS ILLUSTRATED BY AN INSTANCE OF CROSS-PRECIPITATION.

机构信息

Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York.

出版信息

J Exp Med. 1934 Mar 31;59(4):519-28. doi: 10.1084/jem.59.4.519.

DOI:10.1084/jem.59.4.519
PMID:19870263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2132333/
Abstract
  1. Antisera to R-salt-azo-benzidine-azo-crystalline egg albumin give precipitates with crystalline egg albumin by virtue of their antidye content. 2. The quantitative course of the reactions with increasing amounts of antigen is very similar for the dye-antidye and egg albumin-anti-egg albumin systems, but differs markedly for the cross reaction between egg albumin and antidye. 3. A possible explanation for the occurrence of this one-sided crossreaction is given in terms of reactive groupings on the antigen and antibody. 4. A qualitative expression of the course of the cross-reaction is given in terms of the laws of classical chemistry.
摘要

  1. 抗 R 盐-偶氮-联苯-偶氮-卵清蛋白抗血清通过其抗染料含量与结晶卵清蛋白产生沉淀物。

  2. 随着抗原量的增加，染料-抗染料和卵清蛋白-抗卵清蛋白系统的反应定量过程非常相似，但卵清蛋白与抗染料之间的交叉反应明显不同。

  3. 抗原和抗体上的反应基团可以解释这种片面交叉反应的发生。

  4. 交叉反应过程的定性表达可以根据经典化学定律来给出。

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QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : THE ROLE OF MULTIPLE REACTIVE GROUPS IN ANTIGEN-ANTIBODY UNION AS ILLUSTRATED BY AN INSTANCE OF CROSS-PRECIPITATION.定量研究沉淀反应：以交叉沉淀实例说明抗原-抗体结合中多个反应基团的作用。
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2
CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : VII. IMMUNOLOGICAL SPECIFICITY OF ANTIGENS PREPARED BY COMBININGalpha- AND beta-GLUCOSIDES OF GLUCOSE WITH PROTEINS.糖蛋白的化学免疫研究：VII. 用葡萄糖的α-和β-糖苷与蛋白质结合制备的抗原的免疫学特异性。
J Exp Med. 1932 Apr 30;55(5):769-80. doi: 10.1084/jem.55.5.769.
3
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J Exp Med. 1932 Mar 31;55(4):555-61. doi: 10.1084/jem.55.4.555.
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A QUANTITATIVE STUDY OF THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND PURIFIED HOMOLOGOUS ANTIBODY.Ⅲ型肺炎球菌多糖与纯化同源抗体沉淀反应的定量研究。
J Exp Med. 1929 Nov 30;50(6):809-23. doi: 10.1084/jem.50.6.809.
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THE SEPARATION OF TYPES AMONG THE PNEUMOCOCCI HITHERTO CALLED GROUP IV AND THE DEVELOPMENT OF THERAPEUTIC ANTISERUMS FOR THESE TYPES.迄今称为第 IV 组的肺炎球菌的分型、以及这些类型的治疗性抗血清的研制。
J Exp Med. 1929 Feb 28;49(3):461-74. doi: 10.1084/jem.49.3.461.
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