对肺炎球菌的生物学分类的进一步研究。

A FURTHER STUDY ON THE BIOLOGIC CLASSIFICATION OF PNEUMOCOCCI.

机构信息

Hospital of The Rockefeller Institute for Medical Research.

出版信息

J Exp Med. 1915 Dec 1;22(6):804-19. doi: 10.1084/jem.22.6.804.

DOI:10.1084/jem.22.6.804

PMID:19867961

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2125380/

Abstract

At least three subgroups of Pneumococcus Type II may be recognized by specific immune reactions. They have been called Subgroups II A, II B, and II X. 2. That the organisms of these three subgroups are biologically related to Pneumococcus Type II is shown by the following facts: (a) Agglutination with Antipneumococcus Serum II. (b) Protection with Antipneumococcus Serum II, except Subgroup II X. (c) Absorption of Antipneumococcus Serum II with typical Type II pneumococcus removes the antibodies for all subgroups, (d) Absorption of Antipneumococcus Serum II with a member of Subgroups II A or II B removes only the antibodies for the homologous subgroup. Absorption of Antipneumococcus Serum II with any given member of Subgroup II X removes the antibodies for that particular strain only. 3. That the three subgroups, although biologically related to Pneumococcus Type II, possess, nevertheless, specific differential characterswhich separate them one from another, is evidenced by thefollowing facts: (a) The organisms of any subgroup are not agglutinated bythe antisera of the other two subgroups. (b) They are not protected against by the sera of the other subgroups. (c) They do not absorb from Antipneumococcus Serum II the specific immune bodies of the other subgroups. 4. Subgroups II A and II B are characterized by immunity reactions identical within the respective group. 5. Subgroup II X consists of heterogeneous strains which do not cross in their immunity reaction with each other or with Subgroups II A or II B.

摘要

至少可以通过特定的免疫反应识别出肺炎球菌 II 型的三个亚群。它们被称为 IIA、IIB 和 IIX 亚群。
这三个亚群的生物体与肺炎球菌 II 型在生物学上是相关的，这可以通过以下事实证明：（a）与抗肺炎球菌血清 II 的凝集反应。（b）用抗肺炎球菌血清 II 进行保护，除了 IIX 亚群。（c）用典型的 II 型肺炎球菌吸收抗肺炎球菌血清 II 会去除所有亚群的抗体。（d）用 IIA 或 IIB 亚群的成员吸收抗肺炎球菌血清 II 只会去除同源亚群的抗体。用 IIX 亚群的任何特定成员吸收抗肺炎球菌血清 II 只会去除该特定菌株的抗体。
尽管这三个亚群在生物学上与肺炎球菌 II 型相关，但它们具有特定的差异特征，将它们彼此区分开来，这可以通过以下事实证明：（a）任何亚群的生物体都不会被其他两个亚群的抗血清凝集。（b）它们不受其他亚群血清的保护。（c）它们不会从抗肺炎球菌血清 II 中吸收其他亚群的特异性免疫体。
IIA 和 IIB 亚群的免疫反应在各自的群体内是相同的。
IIX 亚群由在免疫反应中彼此不交叉或与 IIA 或 IIB 亚群不交叉的异质菌株组成。