葡萄球菌的免疫学特异性：I. 血清型的出现。
THE IMMUNOLOGICAL SPECIFICITY OF STAPHYLOCOCCI : I. THE OCCURRENCE OF SEROLOGICAL TYPES.
机构信息
Oscar Johnson Institute, Washington University School of Medicine, St. Louis.
出版信息
J Exp Med. 1935 Jun 30;62(1):11-21. doi: 10.1084/jem.62.1.11.
Abstract
- Agglutination is not a precise method for the demonstration of serological types among staphylococci. 2. Precipitation of soluble specific substance derived from these organisms demonstrates the existence of at least two immunologically distinct types. 3. The one type, designated A, is composed of apparently virulent strains, while the other, Type B, contains the avirulent strains. 4. Precipitation tests performed with centrifugates of young broth cultures or with acid extracts of sedimented bacteria may also demonstrate type specificity. 5. Lysis by bacteriophage fails to detect the specific types of Staphylococcus. 6. Immunization by intravenous methods stimulates agglutinin formation in all rabbits and precipitin formation in only one of three or four animals. 7. Immunization by repeated intracutaneous injections of dead staphylococci or living organisms in an agar focus also stimulates agglutinin formation but fails to incite the formation of type specific precipitins.
摘要
凝聚反应不能准确地用于葡萄球菌的血清型鉴定。
从这些生物体中提取的可溶性特异物质沉淀证明至少存在两种免疫上不同的型。
一个型，称为 A 型，由明显的毒性菌株组成，而另一个型，B 型，则含有非毒性菌株。
用年轻肉汤培养物的离心沉淀物或沉降细菌的酸提取物进行的沉淀试验也可以证明型特异性。
噬菌体裂解不能检测到葡萄球菌的特异性型。
通过静脉内方法免疫可刺激所有兔子产生凝集素，而只有三到四只动物中的一只产生沉淀素。
通过反复皮下注射死葡萄球菌或在琼脂焦点中的活生物体进行免疫也可刺激凝集素的形成，但不能引起特定型沉淀素的形成。
相似文献
1
THE IMMUNOLOGICAL SPECIFICITY OF STAPHYLOCOCCI : I. THE OCCURRENCE OF SEROLOGICAL TYPES.葡萄球菌的免疫学特异性：I. 血清型的出现。
J Exp Med. 1935 Jun 30;62(1):11-21. doi: 10.1084/jem.62.1.11.
2
THE COMPOSITE NATURE OF A PURE CULTURE OF A VIRULENT PNEUMOCOCCUS.一株强毒肺炎球菌纯培养物的复合特性。
J Exp Med. 1925 Apr 30;41(5):649-62. doi: 10.1084/jem.41.5.649.
3
LOSS OF THE PROPERTIES OF HEMOLYSIN AND PIGMENT FORMATION WITHOUT CHANGE IN IMMUNOLOGICAL SPECIFICITY IN A STRAIN OF STREPTOCOCCUS HAEMOLYTICUS.溶血素和色素形成特性丧失而免疫特异性不变的一株溶血性链球菌。
J Exp Med. 1934 Mar 31;59(4):459-69. doi: 10.1084/jem.59.4.459.
4
A STUDY OF PNEUMOCOCCI REACTING WITH ANTIPNEUMOCOCCUS SERA OF TYPES I, II, AND III, WITH AN OBSERVATION OF A MUTATION OF ONE OF THE STRAINS.Ⅰ、Ⅱ、Ⅲ型肺炎球菌与抗肺炎球菌血清反应的研究，以及一株菌的突变观察。
J Exp Med. 1919 Aug 1;30(2):123-46. doi: 10.1084/jem.30.2.123.
5
VARIATION AND TYPE SPECIFICITY IN THE BACTERIAL SPECIES HEMOPHILUS INFLUENZAE.流感嗜血杆菌的细菌种属变异性和类型特异性。
J Exp Med. 1931 Mar 31;53(4):471-92. doi: 10.1084/jem.53.4.471.
6
STUDIES ON THE TUBERCULIN REACTION AND ON SPECIFIC HYPERSENSITIVENESS IN BACTERIAL INFECTION.关于结核菌素反应和细菌性感染特异性过敏的研究。
J Exp Med. 1921 Oct 31;34(5):495-524. doi: 10.1084/jem.34.5.495.
7
Cross-reactions among Group A streptococci. I. Precipitin and bactericidal cross-reactions among types 33, 41, 43, 52, and Ross.A组链球菌之间的交叉反应。I. 33型、41型、43型、52型和罗斯型之间的沉淀素和杀菌交叉反应。
J Exp Med. 1968 Nov 1;128(5):959-68. doi: 10.1084/jem.128.5.959.
8
The behavior of virulent and avirulent staphylococci in the tissues of normal mice.有毒力和无毒力葡萄球菌在正常小鼠组织中的行为。
J Exp Med. 1956 Jan 1;103(1):87-108. doi: 10.1084/jem.103.1.87.
9
STUDIES ON NATURAL IMMUNITY TO PNEUMOCOCCUS TYPE III : II. CERTAIN DISTINGUISHING PROPERTIES OF TWO STRAINS OF PNEUMOCOCCUS TYPE III VARYING IN THEIR VIRULENCE FOR RABBITS, AND THE REAPPEARANCE OF THESE PROPERTIES FOLLOWING R-->S RECONVERSION OF THEIR RESPECTIVE ROUGH DERIVATIVES.肺炎球菌Ⅲ型天然免疫的研究：Ⅱ. 两种兔体毒力不同的肺炎球菌Ⅲ型菌株的某些鉴别特性，以及各自粗糙型衍生物 R-->S 回复突变后这些特性的再现。
J Exp Med. 1936 Jul 31;64(2):281-305. doi: 10.1084/jem.64.2.281.
10
Serological reactions associated with the clumping factor of Staphylococcus aureus.与金黄色葡萄球菌凝聚因子相关的血清学反应。
J Bacteriol. 1966 Feb;91(2):588-94. doi: 10.1128/jb.91.2.588-594.1966.
引用本文的文献
1
THE IMMUNOLOGICAL SPECIFICITY OF STAPHYLOCOCCI : II. THE CHEMICAL NATURE OF THE SOLUBLE SPECIFIC SUBSTANCES.葡萄球菌的免疫学特异性：Ⅱ.可溶性特异物质的化学性质。
J Exp Med. 1935 Jun 30;62(1):23-30. doi: 10.1084/jem.62.1.23.
2
STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : I. THE EFFECT OF REPEATED SKIN INFECTIONS.关于葡萄球菌感染发病机制的研究：I. 重复皮肤感染的影响。
J Exp Med. 1961 Jan 31;113(2):235-48. doi: 10.1084/jem.113.2.235.
3
[Mechanical destruction and extraction of bacteria].[细菌的机械破坏与提取]
Z Hyg Infektionskr. 1951;132(6):519-28.
4
[Serological examination of pyogenic Staphylococcus].[化脓性葡萄球菌的血清学检查]
Z Hyg Infektionskr. 1957;144(3):238-47.
本文引用的文献
1
IMMUNOLOGICAL RELATIONSHIPS OF CELL CONSTITUENTS OF PNEUMOCOCCUS : SECOND PAPER.肺炎球菌细胞成分的免疫学关系：第二篇论文。
J Exp Med. 1925 Aug 31;42(3):367-76. doi: 10.1084/jem.42.3.367.
Zotero 插件