Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1936 Mar 31;63(4):491-507. doi: 10.1084/jem.63.4.491.
The white mouse, the guinea pig, the calf, and probably the rat, were found to be susceptible to infection with the virus of rabbit pox. Serial transmission of the virus in mice by brain to brain passage was characterized by a fatal outcome usually on the 5th or 6th day after inoculation. Infection of the guinea pig was accomplished by intratesticular injection and the virus was continued to the 2nd passage in this species. Guinea pigs developed a well marked cutaneous reaction from the intradermal injection of both rabbit and guinea pig tissue virus. Active virus was demonstrated in the testicles of rats 8 days after intratesticular injection by rabbit subinoculation. In the calf inoculation of the scarified skin was followed by the development of large papular lesions with marked hemorrhage and necrosis. The results of the investigations on the etiology of rabbit pox and of the experimentally induced infection reported in this and the four preceding papers (1-4) are discussed with special reference to the relation of pox virus to other viruses and of rabbit pox to other pock diseases.
小白鼠、豚鼠、小牛，可能还有大鼠，均易感染兔痘病毒。通过脑内传代，病毒在小白鼠中连续传播，接种后通常在第 5 或第 6 天导致死亡。豚鼠通过睾丸内注射感染，该病毒在该种动物中连续传至第 2 代。豚鼠皮内注射兔和豚鼠组织病毒后，会出现明显的皮肤反应。用兔再次接种可在接种后 8 天的大鼠睾丸中检出活病毒。小牛经划痕皮肤接种后，会出现大的丘疹性病变，伴有明显的出血和坏死。本文及之前的 4 篇论文（1-4）报告了对兔痘病因和实验性感染的研究结果，特别讨论了痘病毒与其他病毒以及兔痘与其他痘病的关系。
