Department of Animal and Plant Pathology, The Rockefeller Institute for Medical Research, Princeton, N. J., and the Hospital of The Rockefeller Institute for Medical Research, New York.
J Exp Med. 1936 Oct 31;64(5):791-801. doi: 10.1084/jem.64.5.791.
Swine inoculated intranasally with human influenza virus alone develop an ill defined, mild, and usually afebrile illness of short duration. At postmortem the anterior lobes of the lungs of such animals contain scant, scattered areas of lobular atelectasis. Transmission of the virus for 5 serial passages through two groups of swine failed noticeably to enhance its pathogenicity for this species. The disease produced in swine by infection with human influenza virus alone is indistinguishable clinically and pathologically from that caused by infection with swine influenza virus alone. Transmission of human influenza virus from swine to swine by contact succeeded in only one of four attempts. Swine inoculated intranasally with a mixture of human influenza virus and H. influenzae suis usually develop a febrile, depressing illness similar to mild swine influenza. The pneumonia encountered in such animals at autopsy is similar to but less extensive than that seen in swine influenza. In some animals H. influenzae suis fails to become established and the disease then seen is identical with that caused by human influenza virus alone. The human influenza virus recovered after 5 serial transfers in swine was immunologically the same as that with which the experiments were begun.
猪单独感染人流感病毒后会出现轻度、非发热、短暂且定义不明确的疾病。死后剖检时，这些动物的肺前叶仅存在少量散在的小叶性肺不张区域。通过对两组猪进行 5 代连续传代，未能明显增强该病毒对该物种的致病性。单独感染人流感病毒引起的猪病在临床上和病理学上与单独感染猪流感病毒引起的猪病无法区分。通过接触将人流感病毒从猪传播给猪只，仅在 4 次尝试中的 1 次获得成功。猪单独经鼻腔接种人流感病毒和乙型流感嗜血杆菌通常会出现发热、抑郁性疾病，类似于轻度猪流感。剖检时发现的肺炎与猪流感相似，但范围较小。在某些动物中，乙型流感嗜血杆菌未定植，此时所见疾病与单独感染人流感病毒相同。在猪中连续传代 5 代后获得的人流感病毒在免疫学上与实验开始时使用的病毒相同。
