Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
J Exp Med. 1931 Jul 31;54(3):349-59. doi: 10.1084/jem.54.3.349.
Swine influenza has been induced in pigs by the intranasal instillation of material from spontaneous cases of the disease as occurring epizootically in eastern Iowa. The experimental disease has the same features as the epizootic. It has been maintained for study by serial passages accomplished either by intranasal instillation or by pen contact. Eight strains of the virus have been established experimentally during three epizootic periods. The clinical disease induced by these eight strains has been in general the same although its severity and mortality have varied. The principal features of the pathology of swine influenza are an exudative bronchitis accompanied by marked damage of the bronchial epithelium and its cilia, a peribronchial round cell infiltration, and massive pulmonary atelectasis. The latter is modified somewhat by a round cell infiltration of the alveolar walls. The lymph nodes, especially the cervical and mediastinal ones, are hyperplastic and edematous. There is usually a mild to moderate, acute splenic tumor. The mucosa of the stomach and colon is congested. The pneumonia following swine influenza is, characteristically, lobular in type and of the same general distribution as the atelectasis. The non-pneumonic areas of lung are extremely edematous and congested.
猪流感已通过在爱荷华州东部偶发性流行病例中鼻内滴注材料的方式在猪中诱发。实验性疾病具有与流行性病相同的特征。它通过鼻内滴注或笔接触进行连续传代来维持研究。在三个流行期间，已经从实验中建立了 8 株病毒。尽管严重程度和死亡率有所不同，但这 8 株病毒引起的临床疾病总体上是相同的。猪流感病理学的主要特征是渗出性支气管炎，伴有明显的支气管上皮及其纤毛损伤、支气管周围圆形细胞浸润和大量肺不张。肺泡壁的圆形细胞浸润使后者略有改变。淋巴结，特别是颈和纵隔淋巴结，增生和水肿。通常有轻度至中度急性脾脏肿瘤。胃和结肠的黏膜充血。猪流感后发生的肺炎具有小叶性特征，与肺不张的分布大致相同。非肺炎区域的肺部极度水肿和充血。
