Institute of Cancer Research and the Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York.
J Exp Med. 1938 Sep 30;68(4):513-28. doi: 10.1084/jem.68.4.513.
A filterable agent resembling the viruses is described. It was encountered in sarcoma 39, a propagable neoplasm of the white rat, and has now been maintained in this species for 28 passages over a period of some 7 months without appreciable loss in virulence. Its chief effect is the production of large abscesses in an animal species comparatively resistant both to viral diseases and suppuration. The white mouse is more susceptible than the white rat, the rabbit less so, and the guinea pig highly resistant. The agent has been repeatedly recovered from sarcoma 39 treated in special ways, but under the ordinary circumstances of routine transplantation it does not manifest itself. As yet there is no certainty on where it came from or how it maintains itself under natural conditions.
一种类似于病毒的可过滤因子被描述出来。它出现在肉瘤 39 中，这是一种可传播的白鼠肿瘤，现在已经在这种物种中维持了 28 代，大约 7 个月的时间，没有明显的毒力损失。它的主要作用是在一种对病毒性疾病和化脓性感染相对具有抵抗力的动物物种中产生大脓肿。小白鼠比大白鼠更易感染，兔子则次之，豚鼠则高度抵抗。该因子已从经过特殊处理的肉瘤 39 中反复被分离出来，但在常规移植的普通情况下，它并不表现出来。目前还不能确定它来自何处，也不能确定它在自然条件下如何维持自身。
