Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, New York.
J Exp Med. 1942 May 1;75(5):481-7. doi: 10.1084/jem.75.5.481.
Copper added to a standard diet often effects a moderate increase in hemoglobin production in anemia due to blood loss. The copper response is quite irregular in contrast to the iron response. In these dogs there is no lack of copper held in reserve stores (liver and spleen) so the reaction is not related to an actual deficiency of the element. An effect upon enzyme complexes related to globin and hemoglobin production is to be considered. Cobalt under similar conditions causes no stimulus to hemoglobin production, rather an inhibitory effect when more than minimal doses are given. The claim that cobalt causes a polycythemia in dogs receives no support from our experiments.
在因失血导致贫血的情况下，标准饮食中添加铜通常会适度促进血红蛋白的生成。与铁的反应相比，铜的反应相当不规则。在这些狗中，储备库（肝脏和脾脏）中没有缺乏铜，因此反应与该元素的实际缺乏无关。应考虑对与球蛋白和血红蛋白生成相关的酶复合物的影响。在类似条件下，钴不会刺激血红蛋白的产生，而是在给予最小剂量以上时会产生抑制作用。我们的实验并未支持钴会导致狗出现红细胞增多症的说法。
