Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, New York.
J Exp Med. 1940 Mar 31;71(4):569-83. doi: 10.1084/jem.71.4.569.
Certain individual amino acids when given to standard anemic dogs cause an increase in new hemoglobin production. Occasional negative experiments are recorded. Glycine, glutamic acid, aspartic acid, cystine, histidine, phenylalanine, and proline when given in 1 gm. doses daily for 2 weeks, increase hemoglobin output on the average 23 to 25 gm. above the control level. This reaction amounts to 25 to 30 per cent of the new hemoglobin produced by the feeding of 300 gm. liver daily for 2 weeks-a standard liver test. Alanine, valine, isoleucine, and arginine in the same dosage increase the hemoglobin output on the average 13 to 17 gm. per 2 weeks over the control level. Leucine, methionine, lysine, tryptophane, and tyrosine fall in a middle group with hemoglobin output of about 20 gm. Isovaleric acid, beta-hydroxybutyric acid, glutaric acid, and asparagine have shown positive effects and the butyrate is unusually potent for hemoglobin production (Table 2). The isomeric and dl-synthetic forms of the amino acids are as effectively utilized in this reaction as are the natural forms.
某些特定的氨基酸被给予标准贫血犬时，会导致新的血红蛋白生成增加。偶尔会记录到负面实验。甘氨酸、谷氨酸、天冬氨酸、半胱氨酸、组氨酸、苯丙氨酸和脯氨酸，以每天 1 克的剂量连续给予 2 周，血红蛋白的生成量平均比对照水平增加 23 至 25 克。这一反应相当于连续 2 周每天给予 300 克肝脏后新生成的血红蛋白的 25%至 30%——这是一个标准的肝脏测试。以相同剂量给予丙氨酸、缬氨酸、异亮氨酸和精氨酸，血红蛋白的生成量平均比对照水平每周增加 13 至 17 克。亮氨酸、蛋氨酸、赖氨酸、色氨酸和酪氨酸属于血红蛋白生成量约为 20 克的中间组。异戊酸、β-羟基丁酸、戊二酸和天冬酰胺显示出积极的效果，丁酸盐对血红蛋白的生成特别有效（表 2）。在这种反应中，氨基酸的立体异构体和 dl-合成形式与天然形式一样有效利用。
