Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, New York.
J Exp Med. 1945 Oct 31;82(5):311-6. doi: 10.1084/jem.82.5.311.
The maximal output ceiling for hemoglobin in anemia due to blood loss is about 60 gm. per week-the dog receiving a rich protein diet plus high iron intake. Ferrous and ferric salts are equally effective. Iron intravenously plus a rich protein diet may push this level up to 90 to 100 gm. per week. Evidently iron absorption is a limiting factor. Maximal output for hemoglobin plus plasma protein in doubly depleted dogs may reach 120 to 130 gm. per week and using intravenous iron may reach 140 to 160 gm. per week. Maximal output for plasma protein alone in hypoproteinemia due to plasmapheresis reaches 60 to 70 gm. per week but this is not the true ceiling. Technically we cannot remove the new plasma protein as fast as it is formed and the hypoproteinemia is not maintained in the face of a rich protein diet intake. Furthermore the evidence points to the protein circulating pool contributing to the accretion of tissue protein in such dogs with a strong positive nitrogen balance and weight gain. Maximal figures for hemoglobin production in anemia run close to 1 gm. hemoglobin per kilo per day. Maximal figures for new hemoglobin plus plasma protein production in anemia and hypoproteinemia using iron given intravenously, may reach 1.5 gm. blood protein per kilo per day. The actual maximal plasma protein production equals about 1 gm. per kilo per day but the true production ceiling cannot be reached by this technique, for reasons given above.
失血导致贫血时血红蛋白的最大输出上限约为每周 60 克。接受富含蛋白质饮食和高铁摄入的狗。亚铁和高铁盐同样有效。静脉内铁加富含蛋白质的饮食可能将这一水平提高到每周 90 到 100 克。显然，铁吸收是一个限制因素。双重耗竭的狗的血红蛋白和血浆蛋白的最大输出可能达到每周 120 到 130 克，使用静脉内铁可能达到每周 140 到 160 克。由于血浆置换导致的低蛋白血症中单独的血浆蛋白最大输出达到每周 60 到 70 克，但这不是真正的上限。从技术上讲，我们不能像形成新的血浆蛋白一样快速去除它，并且在富含蛋白质的饮食摄入下，低蛋白血症无法维持。此外，有证据表明，在这种具有强烈正氮平衡和体重增加的狗中，循环蛋白池有助于组织蛋白的积累。血红蛋白生成的最大数值接近每天每公斤 1 克血红蛋白。使用静脉内给予的铁，贫血和低蛋白血症中血红蛋白和新的血红蛋白加血浆蛋白生成的最大数值可能达到每天每公斤 1.5 克血蛋白。实际的最大血浆蛋白生成等于每天每公斤约 1 克，但由于上述原因，这种技术无法达到真正的生产上限。
