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THE INFLUENCE OF INJECTIONS OF HOMOLOGOUS HEMOGLOBIN ON THE KIDNEYS OF NORMAL AND DEHYDRATED ANIMALS.同源血红蛋白注射对正常和脱水动物肾脏的影响。
J Exp Med. 1947 Jul 31;86(2):153-8. doi: 10.1084/jem.86.2.153.
2
Acute renal failure in man: new aspects concerning pathogenesis. A morphometric study.人类急性肾衰竭：发病机制的新方面。一项形态计量学研究。
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THE PATHOGENESIS OF THE RENAL INJURY PRODUCED IN THE DOG BY HEMOGLOBIN OR METHEMOGLOBIN.血红蛋白或高铁血红蛋白致犬肾损伤的发病机制。
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IV. HEMOGLOBIN INJECTIONS AND CONSERVATION OF PIGMENT BY KIDNEY, LIVER AND SPLEEN : THE INFLUENCE OF DIET AND BLEEDING.四、血红蛋白注射及肾脏、肝脏和脾脏对色素的保存：饮食和出血的影响。
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Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells.触珠蛋白或血红素结合蛋白疗法可预防长时间储存红细胞后复苏的急性不良反应。
Circulation. 2016 Sep 27;134(13):945-60. doi: 10.1161/CIRCULATIONAHA.115.019955. Epub 2016 Aug 11.
2
The influence of available fluid on the production of experimental hemoglobinuric nephrosis in rabbits.有效液体量对家兔实验性血红蛋白尿性肾病产生的影响。
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3
The role of aciduria in the development of hemoglobinuric nephrosis in dehydrated rabbits.酸性尿在脱水兔血红蛋白尿性肾病发展中的作用。
J Exp Med. 1950 Jul 1;92(1):11-23. doi: 10.1084/jem.92.1.11.
4
EXPERIMENTAL STUDIES IN ACUTE RENAL FAILURE. II. FINE STRUCTURE CHANGES IN TUBULES ASSOCIATED WITH RENAL FAILURE INDUCED BY GLOBIN.急性肾衰竭的实验研究。II. 与珠蛋白诱导的肾衰竭相关的肾小管超微结构变化。
J Exp Med. 1964 Dec 1;120(6):1139-50. doi: 10.1084/jem.120.6.1139.

本文引用的文献

1
HEMOGLOBIN PRECIPITATION IN RENAL TUBULES : A STUDY OF ITS CAUSES AND EFFECTS.血红蛋白在肾小管中的沉淀：病因与影响研究。
J Exp Med. 1945 Oct 31;82(5):361-74. doi: 10.1084/jem.82.5.361.
2
EFFECTS OF SPONTANEOUS DISEASE ON ORGAN WEIGHTS OF RABBITS.自发性疾病对家兔器官重量的影响。
J Exp Med. 1926 Jan 31;43(2):241-62. doi: 10.1084/jem.43.2.241.

同源血红蛋白注射对正常和脱水动物肾脏的影响。

THE INFLUENCE OF INJECTIONS OF HOMOLOGOUS HEMOGLOBIN ON THE KIDNEYS OF NORMAL AND DEHYDRATED ANIMALS.

机构信息

Department of Pathology, University of Wisconsin Medical School, Madison.

出版信息

J Exp Med. 1947 Jul 31;86(2):153-8. doi: 10.1084/jem.86.2.153.

DOI:10.1084/jem.86.2.153
PMID:19871663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2135723/
Abstract
  1. Dehydration, if sufficiently prolonged, favors the accumulation of hemoglobin or its derivatives in the kidneys of rabbits, principally casts formed in the distal convoluted tubules. 2. Once pigment casts have been produced in the distal convoluted tubules, there is obstruction, with atrophy and dilatation of the tubules proximal to the obstruction. 3. When the involvement is sufficiently extensive, there is elevation of the non-protein nitrogen and some animals die because of renal failure.
摘要

  1. 脱水如果持续时间足够长，会有利于兔肾脏中血红蛋白或其衍生物的积累，主要是在远曲小管中形成的管型。

  2. 一旦在远曲小管中形成了色素管型，就会发生阻塞，阻塞近端的小管会出现萎缩和扩张。

  3. 当涉及的范围足够广泛时，会导致非蛋白氮升高，有些动物会因为肾衰竭而死亡。