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HEMOGLOBIN PRECIPITATION IN RENAL TUBULES : A STUDY OF ITS CAUSES AND EFFECTS.血红蛋白在肾小管中的沉淀：病因与影响研究。
J Exp Med. 1945 Oct 31;82(5):361-74. doi: 10.1084/jem.82.5.361.
2
Acute renal failure in man: new aspects concerning pathogenesis. A morphometric study.人类急性肾衰竭：发病机制的新方面。一项形态计量学研究。
Am J Nephrol. 1990;10(5):374-88. doi: 10.1159/000168153.
3
Blood transfusion studies; the relationship of hemoglobinemia and of the pH of the urine to renal damage produced by injection of hemoglobin solutions into dogs.输血研究；血红蛋白血症及尿液pH值与给狗注射血红蛋白溶液所致肾损害的关系。
J Lab Clin Med. 1947 Mar;32(3):223-61.
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The renal lesion associated with hemoglobinemia. I. Its production and functional evolution in the rat.与血红蛋白血症相关的肾脏病变。I. 其在大鼠中的产生及功能演变
J Exp Med. 1966 Mar 1;123(3):523-35. doi: 10.1084/jem.123.3.523.
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THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : II. THE RELATION OF HEMOGLOBINEMIA TO HEMOGLOBINURIA AND JAUNDICE IN NORMAL AND SPLENECTOMIZED ANIMALS.脾与血液破坏和再生及溶血性黄疸的关系：Ⅱ.正常动物和脾切除动物的血红蛋白血症与血红蛋白尿及黄疸的关系。
J Exp Med. 1912 Sep 1;16(3):375-94. doi: 10.1084/jem.16.3.375.
6
Morphologic effects following massive exchange transfusions with a stroma-free hemoglobin solution. II. Kidney.用无基质血红蛋白溶液进行大量换血后的形态学效应。II. 肾脏
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The renal lesion associated with hemoglobinemia. II. Its structural characteristics in the rat.与血红蛋白血症相关的肾脏病变。II. 大鼠的结构特征。
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THE PATHOGENESIS OF THE RENAL INJURY PRODUCED IN THE DOG BY HEMOGLOBIN OR METHEMOGLOBIN.血红蛋白或高铁血红蛋白致犬肾损伤的发病机制。
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Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies.长期接触镉的大鼠肾脏结构和功能的变化。I. 生化和组织病理学研究。
Arch Toxicol. 2003 Jun;77(6):344-52. doi: 10.1007/s00204-003-0451-1. Epub 2003 Mar 12.
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EXPERIMENTAL NEPHRITIS IN THE FROG : IV. THE SIGNIFICANCE OF THE FUNCTIONAL RESPONSE TO VASCULAR AND TO PARENCHYMAL DISTURBANCES IN THE KIDNEY.蛙类实验性肾炎 IV. 肾脏血管和实质病变的功能反应的意义。
J Exp Med. 1932 Jan 31;55(2):295-305. doi: 10.1084/jem.55.2.295.

引用本文的文献

1
THE INFLUENCE OF INJECTIONS OF HOMOLOGOUS HEMOGLOBIN ON THE KIDNEYS OF NORMAL AND DEHYDRATED ANIMALS.同源血红蛋白注射对正常和脱水动物肾脏的影响。
J Exp Med. 1947 Jul 31;86(2):153-8. doi: 10.1084/jem.86.2.153.
2
Effects of proteinuria on the kidney; proteinuria, renal enlargement, and renal injury consequent on protracted parenteral administration of protein solutions in rats.蛋白尿对肾脏的影响；大鼠长期胃肠外给予蛋白质溶液导致的蛋白尿、肾脏肿大及肾损伤。
J Exp Med. 1949 Jun 1;89(6):643-68. doi: 10.1084/jem.89.6.643.
3
The role of aciduria in the development of hemoglobinuric nephrosis in dehydrated rabbits.酸性尿在脱水兔血红蛋白尿性肾病发展中的作用。
J Exp Med. 1950 Jul 1;92(1):11-23. doi: 10.1084/jem.92.1.11.
4
EXPERIMENTAL STUDIES IN ACUTE RENAL FAILURE. II. FINE STRUCTURE CHANGES IN TUBULES ASSOCIATED WITH RENAL FAILURE INDUCED BY GLOBIN.急性肾衰竭的实验研究。II. 与珠蛋白诱导的肾衰竭相关的肾小管超微结构变化。
J Exp Med. 1964 Dec 1;120(6):1139-50. doi: 10.1084/jem.120.6.1139.

本文引用的文献

1
STUDIES CONCERNING THE SITE OF RENIN FORMATION IN THE KIDNEY : IV. THE RENIN CONTENT OF THE MAMMALIAN KIDNEY FOLLOWING SPECIFIC NECROSIS OF PROXIMAL CONVOLUTED TUBULAR EPITHELIUM.关于肾素形成部位的研究：IV. 哺乳动物肾脏近曲小管上皮细胞特异性坏死后肾素含量的变化。
J Exp Med. 1943 Jan 1;77(1):65-70. doi: 10.1084/jem.77.1.65.
2
THE RENAL CLEARANCE OF HEMOGLOBIN IN THE DOG.血红蛋白在狗体内的肾清除率。
J Exp Med. 1940 Jul 31;72(2):149-65. doi: 10.1084/jem.72.2.149.

血红蛋白在肾小管中的沉淀：病因与影响研究。

HEMOGLOBIN PRECIPITATION IN RENAL TUBULES : A STUDY OF ITS CAUSES AND EFFECTS.

机构信息

Department of Pathology, Pathological Institute, McGill University, Montreal.

出版信息

J Exp Med. 1945 Oct 31;82(5):361-74. doi: 10.1084/jem.82.5.361.

DOI:10.1084/jem.82.5.361
PMID:19871506
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2135560/
Abstract
  1. A readily reproducible pathological lesion closely resembling that typical of the "transfusion kidney" has been obtained by the injection of hemoglobin into rabbits having acid urine, whose renal tubules had previously been damaged to a moderate degree by (a) a short period of complete renal ischemia, or (b) the administration of a specific chemical poison-sodium tartrate. 2. It has been found that hemoglobin is precipitated in the tubules of damaged kidneys excreting either acid or alkaline urine, in contrast to the absence of hemoglobin precipitation in normal kidneys. 3. In the acid state hemoglobin casts are more numerous and more persistent than in the alkaline, and are associated with renal functional disturbances, in contrast to the lack of such disturbances when the urine is alkaline. 4. The ultimate outcome, both anatomically and functionally, in any given instance is determined by variations in the degree of tubular damage, the level of hemoglobinemia, and the urinary pH.
摘要

  1. 通过向尿液呈酸性且肾小管先前已被（a）短期完全肾缺血或（b）特定化学毒物酒石酸钠处理而受到中度损害的兔子体内注射血红蛋白，已经获得一种可重现的、类似于“输血肾”的典型病理损伤。

  2. 已经发现，在排泄酸性或碱性尿液的受损肾脏的肾小管中，血红蛋白沉淀，而在正常肾脏中则没有血红蛋白沉淀。

  3. 在酸性状态下，血红蛋白管型比碱性状态下更多且更持久，并且与肾功能障碍有关，而当尿液呈碱性时则没有这种障碍。

  4. 在任何特定情况下，无论是在解剖学上还是在功能上，最终结果都取决于肾小管损伤的程度、血红蛋白血症的水平和尿液 pH 值的变化。