Section of Preventive Medicine of Yale University School of Medicine, New Haven.
J Exp Med. 1947 Sep 30;86(4):309-23. doi: 10.1084/jem.86.4.309.
Although rhesus monkeys have been generally regarded as refractory to infection with poliomyelitis virus administered by the oral route, two of seven infant rhesus developed paralytic poliomyelitis when fed murine-adapted strains of virus. Preliminary intranasal treatment with zinc sulfate and negative serial sections of the olfactory bulbs of the positive animals ruled out the possibility that infection occurred by way of the olfactory pathway. Studies on the distribution of virus in the tissues of the infected animals yielded positive results in one animal only. In this instance, virus was widely distributed throughout the body being isolated from spinal cord, buccal mucosa, duodenal wall, colon contents, superficial lymph nodes, spleen, heart, and adrenals.
虽然恒河猴通常被认为不易通过口服途径感染脊髓灰质炎病毒,但在喂食经过鼠适应的病毒株后,有 7 只幼恒河猴中有 2 只发生了麻痹性脊髓灰质炎。对阳性动物的嗅球进行鼻内硫酸锌预处理和连续阴性切片排除了感染通过嗅觉途径发生的可能性。对感染动物组织中病毒分布的研究仅在 1 只动物中获得阳性结果。在这种情况下,病毒在全身广泛分布,从脊髓、口腔黏膜、十二指肠壁、结肠内容物、浅表淋巴结、脾、心和肾上腺中分离出来。