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[接种减毒活疫苗(Sabin疫苗)的猴子中的脊髓灰质炎病毒感染]

[Poliovirus infection in monkeys vaccinated with live Sabin vaccine].

作者信息

Beĭkin Ia B, Erman B A, Vlasova L V, Vaserin Iu I, Livshits A A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1980(2):84-9.

PMID:6249057
Abstract

An account of the findings resulting from the study of experimental poliomyelitis in M. rhesus after several immunizations with Sabin live vaccine is given. The challenge of the vaccinated monkeys with the virulent strain of poliomyelitis virus, type I, was shown to result in the development of a disease with clinical and morphological characteristics typical of poliomyelitis in some of these monkeys. The incidence of the infection was found to decrease with the growth of antibody level in the blood of the monkeys. The virus was isolated from the tissues of the vaccinated animals showing the symptoms of the disease less frequently than from the tissues of the control animals.

摘要

本文介绍了用萨宾活疫苗多次免疫恒河猴后,对实验性脊髓灰质炎研究所得的结果。给接种疫苗的猴子接种I型脊髓灰质炎病毒强毒株后,发现其中一些猴子出现了具有脊髓灰质炎典型临床和形态学特征的疾病。随着猴子血液中抗体水平的升高,感染发生率降低。与对照动物的组织相比,从出现疾病症状的接种动物组织中分离出病毒的频率较低。

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