Eggers H J
Institut für Virologie, Universität zu Köln, Federal Republic of Germany.
Med Microbiol Immunol. 1990;179(6):297-306. doi: 10.1007/BF00189608.
Despite extensive investigations over the last decades, several aspects of the pathogenesis of enterovirus infections in humans and animals are only poorly understood, such as the molecular basis of virulence (in particular of neurovirulence), tissue tropisms (e.g. the precise site of initial virus replication in the human intestinal tract), and precipitating factors of paralytic disease ("disposition"). Studies on poliovirus myocarditis in man are reviewed. Unequivocal evidence on replication of poliovirus type 2 (strains MEF1 and Lansing) in newborn and suckling mice and on poliovirus myocarditis is presented. Our observations strengthen the thesis of similar pathogenic potentials of the enterovirus group.
尽管在过去几十年里进行了广泛的研究，但人类和动物肠道病毒感染发病机制的几个方面仍了解甚少，如毒力的分子基础（特别是神经毒力）、组织嗜性（例如人类肠道中病毒初始复制的确切部位）以及麻痹性疾病的诱发因素（“易感性”）。本文综述了关于人类脊髓灰质炎病毒心肌炎的研究。文中给出了2型脊髓灰质炎病毒（MEF1和兰辛毒株）在新生和乳鼠中复制以及脊髓灰质炎病毒心肌炎的确凿证据。我们的观察结果强化了肠道病毒组具有相似致病潜力的论点。
