Laboratories of The Rockefeller Institute for Medical Research.
J Gen Physiol. 1924 Jul 20;6(6):747-57. doi: 10.1085/jgp.6.6.747.
Measurements have been made of the solubility at 25 degrees C. of tyrosine in hydrochloric acid and in sodium hydroxide solutions varying from 0.001 to 0.05 M, and also in distilled water. The pH of the saturated solutions was measured with the hydrogen electrode. The following values for the ionization constants of tyrosine have been obtained from the measurements: k(b) = 1.57 x 10(-12), k(a1) = 7.8 x 10(-10), k(a2) = 8.5 x 10(-11). The changes in solubility with pH can be satisfactorily explained by the use of these ionization constants.
测量了 25°C 时酪氨酸在盐酸和氢氧化钠溶液（浓度从 0.001 到 0.05 M 不等）以及蒸馏水中的溶解度。用氢电极测量了饱和溶液的 pH 值。从这些测量中得到了酪氨酸的离解常数的以下值：k(b) = 1.57 x 10(-12)，k(a1) = 7.8 x 10(-10)，k(a2) = 8.5 x 10(-11)。使用这些离解常数可以很好地解释溶解度随 pH 值的变化。
