Entomological Laboratory of the Bussey Institution, Harvard University, Boston.
J Gen Physiol. 1926 Mar 20;9(4):433-43. doi: 10.1085/jgp.9.4.433.
A micro burette, micro pipette, and methods for their use in quantitative toxicological investigations on mandibulate insects are described. It is suggested that the form of curves relating speed of toxic action to dosage may be explained by postulating suitable changes in rate of distribution, excretion, and cell penetration of poison as dosage varies. The speed of toxic action of pentavalent arsenic in the silkworm is proportional to an integral power of the dosage at lower concentrations, and to a fractional power of the dosage at higher concentrations.
描述了一种微量吸管、微量移液器，以及在节肢动物定量毒理学研究中使用它们的方法。有人提出，随着剂量的变化，通过假设合适的分布、排泄和细胞穿透率的变化，可能解释与毒效速度相关的曲线形式。在较低浓度下，五价砷在蚕中的毒效速度与剂量的整数幂成正比，而在较高浓度下则与剂量的分数幂成正比。
