有关离体 Ringer 灌注蛙肝分泌活动性质的研究：I. 一对染料的差异分泌。
STUDIES CONCERNING THE NATURE OF THE SECRETORY ACTIVITY OF THE ISOLATED RINGER-PERFUSED FROG LIVER : I. THE DIFFERENTIAL SECRETION OF PAIRS OF DYESTUFFS.
机构信息
Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia.
出版信息
J Gen Physiol. 1939 Nov 20;23(2):185-90. doi: 10.1085/jgp.23.2.185.
The isolated Ringer-perfused frog liver is able to concentrate in its secretion several hundred or even thousand times a great number of dyestuffs. When two dyestuffs are perfused simultaneously, the liver separates them to a lower or higher degree, some times to such an extent that the secretion of one of them is entirely suppressed by the other. Which one of the two dyestuffs appears prevailingly in the secretion, does not depend upon its diffusibility or lipoid solubility, but perhaps upon its adsorbability. This is concluded from the fact that dyestuffs provided with several (4 to 5) strongly hydrophilic sulfonate groups in their molecule, are not permitted to pass the gland.
离体灌流蛙肝能将许多染料浓缩在其分泌液中达几百倍甚至几千倍。当两种染料同时灌流时，肝脏对它们的分离程度有高有低，有时高到其中一种染料的分泌完全被另一种所抑制。在分泌液中占优势的究竟是哪一种染料，并不取决于其扩散性或类脂溶性，而可能取决于其吸附性。这可从下述事实得出结论：即在其分子中具有 4 到 5 个强亲水性磺酸盐基团的染料，是不能透过腺体的。
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