鲶鱼外周神经激素的活性。

THE ACTIVITY OF PERIPHERALLY STORED NEUROHUMORS IN CATFISHES.

Biological Laboratories, Harvard University, Cambridge.

J Gen Physiol. 1941 Nov 20;25(2):177-84. doi: 10.1085/jgp.25.2.177.

Abstract

Adrenalin when mixed with olive oil 1:100 and injected subcutaneously into a catfish will produce a marked pale spot and a general blanching of the whole fish. The general blanching will disappear in about a day. The pale spot may last 3 to 4 weeks. 2. Injections of adrenalin in oil 1:1000 to 1:10,000,000 cause the formation of only pale spots in catfishes. Adrenalin in oil 1:100,000,000 has no effect on the fish's color. 3. Acetylcholine, though ordinarily more powerful than adrenalin, when mixed with oil is effective only in high concentrations 1:20 to 1:100. It then produces clusters of moderately dark spots. 4. The pale spot on a catfish due to adrenalin in oil may be temporarily obliterated by intermedin. It will return of itself, and this process may be repeated a number of times. The same is true of the dark spots produced by acetylcholine in oil when subjected to adrenalin. These observations indicate the subcutaneous storage of both adrenalin and acetylcholine in oil. 5. In the natural color changes in catfishes the nervous neurohumors, probably also adrenalin and acetylcholine, appear both to be stored in the fish's lipoids and to serve thus as a means of lenghthening the times of initial color responses till these stores of neurohumors are exhausted.

摘要

将肾上腺素与橄榄油以 1:100 的比例混合，然后皮下注射到鲶鱼体内，会导致鱼体出现明显的苍白斑点和整体变白。这种整体变白的现象大约会持续一天。苍白斑点可能会持续 3 到 4 周。
以 1:1000 到 1:10000000 的浓度将肾上腺素注射入鲶鱼体内，只会导致鱼体出现苍白斑点。而浓度达到 1:100000000 的肾上腺素对鱼的颜色没有影响。
乙酰胆碱通常比肾上腺素更有效，但与油混合后，只有在高浓度 1:20 到 1:100 时才有效。此时，它会产生中等大小的深色斑点簇。
由于油中的肾上腺素导致的鲶鱼苍白斑点可以暂时被中介素所消除。它会自行恢复，这个过程可能会重复多次。当油中的乙酰胆碱受到肾上腺素作用而产生的深色斑点也是如此。这些观察结果表明，肾上腺素和乙酰胆碱都以油的形式储存在鲶鱼的脂类中，从而作为延长神经递质初始颜色反应时间的一种手段，直到这些神经递质储存耗尽。
在鲶鱼的自然颜色变化中，神经神经递质，可能还包括肾上腺素和乙酰胆碱，似乎都储存在鱼的脂类中，从而作为延长神经递质初始颜色反应时间的一种手段，直到这些神经递质储存耗尽。