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本文引用的文献

1
ANTIGENIC PROPERTIES OF NATIVE AND REGENERATED HORSE SERUM ALBUMIN.天然马血清白蛋白和再生马血清白蛋白的抗原特性。
J Exp Med. 1943 Jul 1;78(1):1-8. doi: 10.1084/jem.78.1.1.
2
THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : II. CONDITIONS FOR QUANTITATIVE PRECIPITATION OF ANTIBODY IN HORSE SERA.Ⅲ型肺炎球菌多糖与同种抗体的沉淀反应：Ⅱ. 马血清中抗体定量沉淀的条件。
J Exp Med. 1935 Mar 31;61(4):559-62. doi: 10.1084/jem.61.4.559.
3
Observations on the crystallizable albumin fraction of horse serum.关于马血清可结晶白蛋白部分的观察报告。
Biochem J. 1938 Mar;32(3):552-62. doi: 10.1042/bj0320552.

天然牛血清白蛋白和再生牛血清白蛋白：二、免疫特性。

NATIVE AND REGENERATED BOVINE ALBUMIN : II. IMMUNOLOGICAL PROPERTIES.

机构信息

Departments of Bacteriology and Biochemistry, Duke University, School of Medicine and Duke Hospital, Durham.

出版信息

J Gen Physiol. 1943 Jul 20;26(6):533-9. doi: 10.1085/jgp.26.6.533.

DOI:10.1085/jgp.26.6.533
PMID:19873365
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2142577/
Abstract
  1. The effects of regeneration of whole bovine albumin on antigenic activity and serological specificity were determined by precipitin measurements on rabbit antisera to (1) native whole albumin, (2) albumin regenerated from 8 M urea, and (3) albumin regenerated from 8 M guanidine hydrochloride. 2. While numerically the mean antibody response to these three antigens was found to decrease in the order named, only the difference in antigenic activity between native and guanidine hydrochloride-regenerated albumin was statistically significant. Native, crystalline, carbohydrate-free albumin (crystalbumin) was considerably less antigenic than native whole bovine albumin, its activity being comparable to, if not less than, that observed for guanidine hydrochloride-regenerated whole albumin. 3. All four antigens were immunologically equivalent. 4. The antigenic activity of these proteins is discussed in terms of protein structure and carbohydrate content.
摘要

  1. 通过对兔抗（1）天然全白蛋白、（2）从 8 M 尿素中再生的白蛋白和（3）从 8 M 盐酸胍中再生的白蛋白的沉淀测量，确定了整个牛白蛋白再生对抗原活性和血清学特异性的影响。

  2. 虽然这三种抗原的平均抗体反应数值上呈递减顺序，但只有天然和盐酸胍再生白蛋白之间的抗原活性差异具有统计学意义。天然、结晶、无碳水化合物白蛋白（结晶白蛋白）的抗原性明显低于天然全牛白蛋白，其活性与盐酸胍再生全白蛋白相当，如果不比其低的话。

  3. 所有四种抗原在免疫学上都是等效的。

  4. 这些蛋白质的抗原活性根据其蛋白质结构和碳水化合物含量进行了讨论。