双糖和单糖对果蝇唇瓣糖受体的刺激作用。
Stimulation of the labellar sugar receptor of the fleshfly by mono- and disaccharides.
机构信息
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
出版信息
J Gen Physiol. 1968 Sep 1;52(3):559-83. doi: 10.1085/jgp.52.3.559.
Responses of the labellar sugar receptor of the fleshfly, Boettcherisca peregrina, were studied over a wide range of concentrations of several sugars (sucrose, maltose, glucose, fructose, and mannose) in single solutions and in mixtures. The results suggest (a) that the receptor sites are not completely differentiated for glucose and for fructose combination, (b) that the receptor site is composed of two subunits. Such suggestions are based on the classical model, where the response is proportional to the number of the sites, two subunits of each site being simultaneously occupied with one molecule of disaccharides or two molecules of monosaccharides. It is shown, however, that an allosteric model gives a somewhat better interpretation of the experimental results.
对美洲大蕈蝇（Boettcherisca peregrina）唇瓣糖受体在多种单糖（蔗糖、麦芽糖、葡萄糖、果糖和甘露糖）浓度下的反应进行了研究。结果表明：（a）受体部位对于葡萄糖和果糖的组合并非完全分化；（b）受体部位由两个亚基组成。这些建议基于经典模型，即响应与结合部位的数量成正比，每个部位的两个亚基同时与一个二糖分子或两个单糖分子结合。然而，结果表明，变构模型对实验结果的解释更为合理。
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