Morita H, Shiraishi A
J Gen Physiol. 1968 Oct;52(4):559-83. doi: 10.1085/jgp.52.4.559.
Responses of the labellar sugar receptor of the fleshfly, Boettcherisca peregrina, were studied over a wide range of concentrations of several sugars (sucrose, maltose, glucose, fructose, and mannose) in single solutions and in mixtures. The results suggest (a) that the receptor sites are not completely differentiated for glucose and for fructose combination, (b) that the receptor site is composed of two subunits. Such suggestions are based on the classical model, where the response is proportional to the number of the sites, two subunits of each site being simultaneously occupied with one molecule of disaccharides or two molecules of monosaccharides. It is shown, however, that an allosteric model gives a somewhat better interpretation of the experimental results.
在单溶液和混合溶液中,研究了肉蝇(棕尾别麻蝇)唇瓣糖受体对几种糖(蔗糖、麦芽糖、葡萄糖、果糖和甘露糖)在广泛浓度范围内的反应。结果表明:(a)葡萄糖和果糖组合的受体位点没有完全分化;(b)受体位点由两个亚基组成。这些建议基于经典模型,即反应与位点数量成正比,每个位点的两个亚基同时被一个二糖分子或两个单糖分子占据。然而,结果表明,变构模型对实验结果的解释更好一些。