Jiang Yong-Nan, Mo Hong-Ying
Guangdong Food and Drug Vocational College, Guangzhou 510520, China.
Zhong Yao Cai. 2009 Jul;32(7):1093-7.
To study the effect of Tankejing Dry Powder inhaler on inflammatory in lung injury of mice infected by influenza virus (FM1).
Model mice infected by influenza virus FM1 were randomly divided into six groups: the nomal group, model group, low dose, medium dose and high dose of Tankejing Dry Powder inhaler group,and Ribavirin group. The following indices including the change of NF-kappaB in lung tissue at 24 h, the changes of TNF-alpha, IL-1beta, IL-6 in lung tissue, the lung index and the death rate were observed.
Compared with model group, medium and high dosages of Tankejing Dry Powder inhaler could modulate the expression of NF-kappaB, reduce the level of TNF-alpha, IL-beta, IL-6 in lung tissue (P < 0.05), and reduce the lung index and the death number of animals within 14 days (P < 0.05).
Tankejing Dry Powder inhaler may reduce the inflammatory injury caused by influenza virus FM1 through regulating the expression level of NF-kappaB and cytokine.
研究痰咳净干粉吸入剂对感染流感病毒（FM1）小鼠肺损伤炎症的影响。
将感染流感病毒FM1的模型小鼠随机分为六组：正常组、模型组、痰咳净干粉吸入剂低剂量组、中剂量组、高剂量组及利巴韦林组。观察以下指标，包括24小时时肺组织中核因子κB（NF-κB）的变化、肺组织中肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）的变化、肺指数及死亡率。
与模型组相比，痰咳净干粉吸入剂中、高剂量可调节NF-κB的表达，降低肺组织中TNF-α、IL-β、IL-6水平（P<0.05），并降低肺指数及14天内动物死亡数（P<0.05）。
痰咳净干粉吸入剂可能通过调节NF-κB及细胞因子表达水平减轻流感病毒FM1所致的炎症损伤。
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