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Structure--activity relationships of polymyxin antibiotics.

作者信息

Velkov Tony, Thompson Philip E, Nation Roger L, Li Jian

机构信息

School of Medicine, Deakin University, Pigdons Road, Geelong 3217, Victoria, Australia.

出版信息

J Med Chem. 2010 Mar 11;53(5):1898-916. doi: 10.1021/jm900999h.

DOI:10.1021/jm900999h
PMID:19874036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2907661/
Abstract
摘要

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本文引用的文献

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Aerosporin, an antibiotic produced by Bacillus aerosporus Greer.气孢菌素，一种由气孢芽孢杆菌格里尔产生的抗生素。
Nature. 1947 Aug 23;159(4060):263. doi: 10.1038/160263a0.
2
Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration.新型抗菌阳离子肽 NAB 7061 和 NAB 739 经静脉给药后在大鼠体内的药代动力学。
J Antimicrob Chemother. 2009 Nov;64(5):1067-70. doi: 10.1093/jac/dkp331. Epub 2009 Sep 10.
3
Development of des-fatty acyl-polymyxin B decapeptide analogs with Pseudomonas aeruginosa-specific antimicrobial activity.
荧光抗生素：在对抗细菌感染中架起诊断与治疗的桥梁。
Small Sci. 2025 May 20;5(7):2500138. doi: 10.1002/smsc.202500138. eCollection 2025 Jul.
4
Rapid identification of key antibiotic resistance genes in using high-resolution genome-scale CRISPRi screening.使用高分辨率基因组规模的CRISPRi筛选快速鉴定[具体研究对象]中的关键抗生素抗性基因。 （注：原文中“in”后面缺少具体内容）
iScience. 2025 Apr 15;28(5):112435. doi: 10.1016/j.isci.2025.112435. eCollection 2025 May 16.
5
The carRS-ompV-virK operon of Vibrio cholerae senses antimicrobial peptides and activates the expression of multiple resistance systems.霍乱弧菌的carRS-ompV-virK操纵子可感知抗菌肽并激活多种抗性系统的表达。
Sci Rep. 2025 Apr 21;15(1):13686. doi: 10.1038/s41598-025-98217-3.
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A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations.成人人群中黏菌素和多黏菌素B药代动力学研究的系统评价
Clin Pharmacokinet. 2025 May;64(5):655-689. doi: 10.1007/s40262-025-01488-2. Epub 2025 Apr 17.
7
Specific labeling of outer membrane vesicles with antibiotic-conjugated probe reveals early bacterial infections in blood.用抗生素偶联探针对外膜囊泡进行特异性标记可揭示血液中的早期细菌感染。
Nat Commun. 2025 Apr 14;16(1):3535. doi: 10.1038/s41467-025-58676-8.
8
Cell-free synthetic biology for natural product biosynthesis and discovery.用于天然产物生物合成与发现的无细胞合成生物学
Chem Soc Rev. 2025 May 6;54(9):4314-4352. doi: 10.1039/d4cs01198h.
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Molecular epidemiology of Escherichia coli in bloodstream infections from a general hospital in Ningxia, China, 2022-2023.2022 - 2023年中国宁夏某综合医院血流感染中大肠杆菌的分子流行病学研究
BMC Infect Dis. 2025 Feb 28;25(1):293. doi: 10.1186/s12879-025-10658-3.
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Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria.导致革兰氏阴性菌对多粘菌素耐药的十一异戊烯基磷酸糖基化的结构基础。
bioRxiv. 2025 Jan 30:2025.01.29.634835. doi: 10.1101/2025.01.29.634835.
具有铜绿假单胞菌特异性抗菌活性的去脂肪酰基多粘菌素B十肽类似物的研发。
Chem Pharm Bull (Tokyo). 2009 Apr;57(4):332-6. doi: 10.1248/cpb.57.332.
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Identification of a polymyxin synthetase gene cluster of Paenibacillus polymyxa and heterologous expression of the gene in Bacillus subtilis.多粘芽孢杆菌多粘菌素合成酶基因簇的鉴定及其在枯草芽孢杆菌中的异源表达。
J Bacteriol. 2009 May;191(10):3350-8. doi: 10.1128/JB.01728-08. Epub 2009 Mar 20.
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Contribution of each amino acid residue in polymyxin B(3) to antimicrobial and lipopolysaccharide binding activity.多粘菌素B(3)中每个氨基酸残基对抗菌和脂多糖结合活性的贡献。
Chem Pharm Bull (Tokyo). 2009 Mar;57(3):240-4. doi: 10.1248/cpb.57.240.
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J Biol Chem. 2009 Apr 24;284(17):11498-506. doi: 10.1074/jbc.M806587200. Epub 2009 Feb 25.
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Nat Rev Microbiol. 2009 Mar;7(3):245-50. doi: 10.1038/nrmicro2095.
8
Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital.一所三级大学附属医院中泛耐药鲍曼不动杆菌的医院感染暴发。
Infect Control Hosp Epidemiol. 2009 Mar;30(3):257-63. doi: 10.1086/595977.
9
Comparison of the structure and dynamics of the antibiotic peptide polymyxin B and the inactive nonapeptide in aqueous trifluoroethanol by NMR spectroscopy.通过核磁共振光谱法比较抗生素多肽多粘菌素B与无活性九肽在三氟乙醇水溶液中的结构和动力学。
J Phys Chem B. 2009 Jan 15;113(2):544-51. doi: 10.1021/jp808379x.
10
Capsule polysaccharide is a bacterial decoy for antimicrobial peptides.荚膜多糖是抗菌肽的细菌诱饵。
Microbiology (Reading). 2008 Dec;154(Pt 12):3877-3886. doi: 10.1099/mic.0.2008/022301-0.