基于六氢哌嗪的 5-HT1A/5-HT7R 配体的新见解：合成与生物评价。
New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.
机构信息
ICOA/University of Orléans, Orléans, France.
出版信息
J Enzyme Inhib Med Chem. 2010 Jun;25(3):301-5. doi: 10.3109/14756360903179393.
PMID:19874209
Abstract
The synthesis of new N-homopiperazinyl-based ligands is reported. Various structural modifications along with the corresponding biological activities on 5-HT(1A)/5-HT(7) receptors give further insights into this class of serotoninergic ligands. Among the tested central heterocyles, the 7-azaindole gave the best results on the above-mentioned receptors.
摘要
本文报道了新型 N-高哌嗪基配体的合成。通过对 5-HT（1A）/5-HT（7）受体的各种结构修饰及相应的生物活性研究，进一步深入探讨了此类血清素能配体。在所测试的中枢杂环中，7-氮吲哚在上述受体上表现出最佳效果。
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