Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
Clin Exp Dermatol. 2010 Apr;35(3):219-22. doi: 10.1111/j.1365-2230.2009.03520.x. Epub 2009 Oct 23.
Palmoplantar pustulosis (PPP) is a common chronic and recurrent pustular dermatosis characterized by multiple sterile pustules and erythematous plaques on the palms and soles. The exact cause and pathogenesis of the disease remain unknown, and there is still debate about whether PPP is a variant of psoriasis or a distinct condition. A review of the medical literature revealed that a wide range of treatments have been used in the treatment of PPP over the years. The literature in PPP is restricted to case reports or small case series, and there is a lack of well-documented clinical studies, which makes it difficult to select an ideal therapy for the condition. The purpose of this review is to discuss the current therapy options for PPP, based on results of randomized controlled trials.
掌跖脓疱病（PPP）是一种常见的慢性复发性脓疱性皮肤病，其特征是手掌和脚底出现多个无菌脓疱和红斑。该病的确切病因和发病机制尚不清楚，关于 PPP 是否是银屑病的一种变体还是一种独特的疾病仍存在争议。对医学文献的回顾表明，多年来，PPP 的治疗方法多种多样。PPP 的文献仅限于病例报告或小病例系列，缺乏有充分记录的临床研究，因此很难为该病选择理想的治疗方法。本综述的目的是根据随机对照试验的结果，讨论 PPP 的当前治疗选择。
