Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Carcinogenesis. 2010 Jan;31(1):59-70. doi: 10.1093/carcin/bgp262. Epub 2009 Oct 29.
The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events and they can disrupt expression of genes. Determination of which adduct is responsible for each of these biological endpoints is difficult, but this task has been accomplished for some carcinogenic DNA-damaging agents. Here, we describe the respective contributions of specific DNA lesions to the biological effects of low molecular weight alkylating agents.
DNA 损伤剂与基因组的反应会导致大量损伤，通常称为加合物。加合物可能导致 DNA 突变，它们可能是致命事件的化学前体，也可能破坏基因的表达。确定哪种加合物负责这些生物学终点中的每一个是困难的，但对于一些致癌 DNA 损伤剂已经完成了这项任务。在这里，我们描述了特定 DNA 损伤对低分子量烷化剂生物效应的各自贡献。
