Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Obesity (Silver Spring). 2010 Jul;18(7):1443-8. doi: 10.1038/oby.2009.375. Epub 2009 Oct 29.
This study included 11,825 participants of a Spanish dynamic prospective cohort based on former students from University of Navarra, registered professionals from some Spanish provinces, and university graduates from other associations, followed-up for 6.1 years. We aimed to assess the association between childhood or young adult overweight/obesity and the risk of depression. Participants were asked to select which of nine figures most closely represented their body shape at ages 5 and 20 years. Childhood and young adult overweight/obesity was defined as those cases in which participants reported body shape corresponding to the figures 6-9 (more obese categories) at age 5 or 20, respectively. A subject was classified as incident case of depression if he/she was initially free of depression and reported physician-made diagnosis of depression and/or the use of antidepressant medication in at least one of biannual follow-up questionnaires. The association between childhood and young adult overweight/obesity and incidence of depression was estimated by multiple-adjusted hazard ratio (HR) and its 95% confidence interval (95% CI). Overweight/obesity at age 5 years predicted an increased risk for adult depression (HR = 1.50, 95% CI = 1.06-2.12), and a stronger association was observed at age 20 years ((HR = 2.22, 95% CI = 1.22-4.08), (subjects younger than 30 years at recruitment were excluded from this last analysis)). Childhood or young adult overweight/obesity was associated with elevated risk of adult depression. These results, if causal and confirmed in other prospective studies, support treating childhood and young adult overweight/obesity as part of comprehensive adult depression prevention efforts.
这项研究纳入了 11825 名来自西班牙纳瓦拉大学的前学生、来自西班牙部分省份的注册专业人员和其他协会的大学毕业生的西班牙动态前瞻性队列研究参与者，随访时间为 6.1 年。我们旨在评估儿童或青年时期超重/肥胖与抑郁风险之间的关系。参与者被要求从 9 个数字中选择哪个最能代表他们在 5 岁和 20 岁时的体型。儿童和青年时期超重/肥胖定义为那些在 5 岁或 20 岁时报告身体形状对应于数字 6-9（更肥胖类别）的病例。如果一个人最初没有抑郁，并在至少一次两年一次的随访问卷中报告了医生做出的抑郁诊断和/或使用抗抑郁药物，则他/她被归类为抑郁的新发病例。通过多因素调整后的风险比（HR）及其 95%置信区间（95%CI）来估计儿童和青年时期超重/肥胖与抑郁发病之间的关系。5 岁时超重/肥胖预测成年后抑郁的风险增加（HR=1.50，95%CI=1.06-2.12），而在 20 岁时观察到更强的关联（HR=2.22，95%CI=1.22-4.08）（排除了招募时年龄小于 30 岁的受试者）。儿童或青年时期超重/肥胖与成年后抑郁风险增加相关。如果这些结果是因果关系的，并在其他前瞻性研究中得到证实，那么将儿童和青年时期超重/肥胖作为综合成年期预防抑郁努力的一部分是合理的。
