Salazar-García S, Ibáñez-Salazar A, Lares-Villaseñor E, Gaytan Pacheco Noemi, Uresti-Rivera E, Portales-Pérez D P, De la Cruz-Mosso U, Vargas-Morales J M
Laboratorio de Análisis Clínicos, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.
Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas ¨Francisco García Salinas, Zacatecas, México.
Front Genet. 2024 Apr 4;15:1278201. doi: 10.3389/fgene.2024.1278201. eCollection 2024.
The high prevalence of obesity in Mexico starting from the early stages of life is concerning and represents a major public health problem. Genetic association studies have reported that single nucleotide variants (SNVs) in , an NADdependent deacetylase that plays an important role in the regulation of metabolic cellular functions, are associated with multiple metabolic disorders and the risk of obesity. In the present study, we analyzed the effect that the SNVs rs1467568 and rs7895833 of the gene may have on cardiometabolic risk factors in a young adult population from Mexico. A cross-sectional study was carried out with young adults between the ages of 18 and 25 who had a body mass index (BMI) greater than 18.5 kg/m. This study included 1122 young adults who were classified into the normal weight ( = 731), overweight group ( = 277), and obesity group ( = 114) according to BMI of whom 405 and 404 volunteers were genotyped for rs1467568 and rs7895833 respectively using TaqMan probes through allelic discrimination assays. We found that the male sex carrying the G allele of rs7895833 had slightly lower BMI levels ( = 0.009). Furthermore, subjects carrying rs1467568 (G allele) showed a 34% lower probability of presenting with hyperbetalipoproteinemia where female carrying rs1467568 had lower levels of total cholesterol ( = 0.030), triglycerides ( = 0.026) and LDL cholesterol ( = 0.013). In conclusion, these findings suggest that the presence of both SNVs could have a non-risk effect against dyslipidemia in the Mexican population.
从生命早期阶段开始，墨西哥肥胖症的高流行率令人担忧，是一个重大的公共卫生问题。基因关联研究报告称， 基因中的单核苷酸变异（SNV）与多种代谢紊乱和肥胖风险相关，该基因是一种NAD依赖性脱乙酰酶，在调节细胞代谢功能中起重要作用。在本研究中，我们分析了 基因的SNV rs1467568和rs7895833对墨西哥年轻成年人群心脏代谢危险因素可能产生的影响。我们对18至25岁、体重指数（BMI）大于18.5kg/m的年轻人进行了一项横断面研究。本研究纳入了1122名年轻人，根据BMI将其分为正常体重组（ = 731）、超重组（ = 277）和肥胖组（ = 114），其中405名和404名志愿者分别使用TaqMan探针通过等位基因鉴别分析对rs1467568和rs7895833进行基因分型。我们发现，携带rs7895833的G等位基因的男性BMI水平略低（ = 0.009）。此外，携带rs1467568（G等位基因）的受试者出现高β脂蛋白血症的概率降低34%，携带rs1467568的女性总胆固醇水平较低（ = 0.030）、甘油三酯水平较低（ = 0.026）和低密度脂蛋白胆固醇水平较低（ = 0.013）。总之，这些发现表明，这两种SNV的存在可能对墨西哥人群的血脂异常具有无风险效应。
