Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Obesity (Silver Spring). 2010 Jun;18(6):1260-5. doi: 10.1038/oby.2009.396. Epub 2009 Oct 29.
The purpose of our study was to determine whether self-reported physical activity (PA), including recreational, household, and exercise activities, is associated with intra-abdominal fat (IAF) in community-dwelling white and black midlife women. We performed a cross-sectional study of 369 women from the Chicago site of the Study of Women's Health Across the Nation (SWAN) ancillary study, the SWAN Fat Patterning Study. PA level was the independent variable, and IAF, assessed by computerized tomography (CT) scan, was the dependent variable. Measures were obtained at SWAN Fat Patterning Baseline visit between August 2002 and December 2005. Linear regression models explored the association between PA and IAF. The first model included IAF as the outcome and total score PA as the main predictor, adjusting for total percent fat mass, age, and ethnicity. The second model included education, parity, sex hormone-binding globulin (SHBG) level, and depressive symptoms, measured by Center for Epidemiological Studies-Depression (CES-D) scale. Each 1-point higher total PA score was associated with a 4.0 cm(2) lower amount of IAF (P = 0.004), independent of total percent fat mass, age, ethnicity, SHBG level, educational level, CES-D, and parity. Associations did not differ between white and black women. This study demonstrates a significant negative association between PA and IAF independent of multiple covariates in midlife women. Our findings suggest that motivating white and black women to increase PA during midlife may lessen IAF, which may have a positive impact on subsequent development of diabetes and cardiovascular disease.
我们的研究目的是确定自我报告的体力活动（PA），包括娱乐、家务和运动活动，是否与社区居住的白人和黑人中年女性的腹部内脏脂肪（IAF）有关。我们对来自妇女健康研究全国辅助研究（SWAN）的芝加哥站点的 369 名女性进行了横断面研究，该研究为 SWAN 脂肪模式研究。PA 水平是自变量，IAF 是通过计算机断层扫描（CT）扫描评估的因变量。在 2002 年 8 月至 2005 年 12 月期间进行了 SWAN 脂肪模式基线访问时获得了测量结果。线性回归模型探索了 PA 与 IAF 之间的关联。第一个模型将 IAF 作为结果，将总 PA 评分作为主要预测因素，同时调整了总脂肪质量百分比、年龄和种族。第二个模型包括教育、生育次数、性激素结合球蛋白（SHBG）水平和抑郁症状，通过流行病学研究中心抑郁量表（CES-D）进行评估。PA 总分每增加 1 分，IAF 就会减少 4.0cm²（P = 0.004），与总脂肪质量百分比、年龄、种族、SHBG 水平、教育程度、CES-D 和生育次数无关。白人和黑人女性之间的关联没有差异。这项研究表明，PA 与 IAF 之间存在显著的负相关，独立于中年女性的多个协变量。我们的研究结果表明，激励白人和黑人女性在中年时期增加 PA 可能会减少 IAF，这可能对随后发生的糖尿病和心血管疾病产生积极影响。
