Dugan Sheila A, Lange-Maia Brittney, Karavolos Kelly, Kazlauskaite Rasa, Hollings Chiquia S, Avery Elizabeth, Nackers Lisa, Lynch Elizabeth, Ventrelle Jennifer, Normand Patricia, Johnson Tricia, Fullam Francis, Shipp-Johnson Karla, Wilbur JoEllen, Powell Lynda H
Department of Preventive Medicine, Rush University Medical Center, Chicago, IL, United States.
Department of Physical Medicine & Rehabilitation, Rush University Medical Center, Chicago, IL, United States.
Contemp Clin Trials Commun. 2016 Jul 20;4:74-83. doi: 10.1016/j.conctc.2016.07.002. eCollection 2016 Dec 15.
Changes in reproductive hormones during menopause are associated with accumulation of intra-abdominal adipose tissue (IAAT), a subclinical indicator of cardiometabolic disease risk. Independent of reproductive hormones, unhealthy lifestyle contributes to IAAT gain. The Women in the Southside Health and Fitness (WISHFIT) Study aims to develop a lifestyle approach to slowing IAAT accumulation as women begin the menopausal transition.
The primary aim is to develop and conduct a proof-of-concept test of a multi-component, multi-level behavioral intervention targeting jointly physical activity, diet, and psychological well-being. Participants attend group sessions over 2 years to experiment with healthy living through both experiential and didactic learning, cultivate a health network, and draw on community resources to sustain change. The primary endpoint is 2-year IAAT progression, assessed using computerized tomography. Behavioral targets of treatment and secondary endpoints will be evaluated at 6, 12, 18 and 24 months. Change in social networks and community support will be assessed at 2 years.
WISHFIT recruited 71 pre- and peri-menopausal Caucasian and African American women (mean ± SD age = 47.6 ± 3.4 yrs; BMI = 33.6 ± 7.3 kg/m; 52% African American). Baseline IAAT was 2104.1 ± 1201.3 cm. IAAT, physical activity, BMI, and self-reported family income and resilience differed by ethnicity at baseline.
WISHFIT is a multi-component, multi-level intervention aimed at producing a sustained improvement in physical activity, diet, and psychological well-being early in the menopausal transition to slow menopause-related accumulation of IAAT. It provides a model for the process of developing a behavioral treatment to manage a chronic disease.
更年期期间生殖激素的变化与腹部内脂肪组织（IAAT）的积累有关，IAAT是心脏代谢疾病风险的亚临床指标。与生殖激素无关，不健康的生活方式也会导致IAAT增加。南区健康与健身女性（WISHFIT）研究旨在制定一种生活方式方法，以减缓女性进入更年期过渡阶段时IAAT的积累。
主要目标是开发并进行一项多成分、多层次行为干预的概念验证测试，该干预同时针对身体活动、饮食和心理健康。参与者在两年内参加小组会议，通过体验式和讲授式学习来尝试健康生活，建立健康网络，并利用社区资源维持改变。主要终点是2年的IAAT进展情况，通过计算机断层扫描进行评估。治疗的行为目标和次要终点将在6、12、18和24个月时进行评估。社交网络和社区支持的变化将在2年时进行评估。
WISHFIT招募了71名绝经前和围绝经期的白种人和非裔美国女性（平均±标准差年龄=47.6±3.4岁；BMI=33.6±7.3kg/m²；52%为非裔美国人）。基线IAAT为2104.1±1201.3cm³。基线时，IAAT、身体活动、BMI以及自我报告的家庭收入和恢复力在不同种族之间存在差异。
WISHFIT是一项多成分、多层次的干预措施，旨在在更年期过渡早期持续改善身体活动、饮食和心理健康，以减缓与更年期相关的IAAT积累。它为开发管理慢性病的行为治疗过程提供了一个模型。
